Occupational COPD and job exposure matrices: a systematic review and meta-analysis
| Autor: | Om P Kurmi, Steven Sadhra, Kin Bong Hubert Lam, Jonathan Geoffrey Ayres, Sandeep S. Sadhra |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Time Factors airborne substances Air Pollutants Occupational Review International Journal of Chronic Obstructive Pulmonary Disease Risk Assessment Occupational safety and health Pulmonary Disease Chronic Obstructive 03 medical and health sciences 0302 clinical medicine Bias Risk Factors Occupational Exposure Environmental health Odds Ratio occupation Humans COPD Medicine 030212 general & internal medicine Occupations job exposure matrices Occupational Health Inhalation exposure Inhalation Exposure business.industry Confounding Dust General Medicine Odds ratio medicine.disease Confidence interval Occupational Diseases 030228 respiratory system Meta-analysis Physical therapy Female Gases Risk assessment business |
| Zdroj: | International Journal of Chronic Obstructive Pulmonary Disease |
| ISSN: | 1178-2005 |
| DOI: | 10.2147/copd.s125980 |
| Popis: | Steven Sadhra,1 Om P Kurmi,2 Sandeep S Sadhra,1 Kin Bong Hubert Lam,2 Jon G Ayres1 1Institute of Occupational and Environmental Medicine, University of Birmingham, Edgbaston, Birmingham, 2Nuffield Department of Population Health, Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, UK Background: The association between occupational exposure and COPD reported previously has mostly been derived from studies relying on self-reported exposure to vapors, gases, dust, or fumes (VGDF), which could be subjective and prone to biases. The aim of this study was to assess the strength of association between exposure and COPD from studies that derived exposure by job exposure matrices (JEMs).Methods: A systematic search of JEM-based occupational COPD studies published between 1980 and 2015 was conducted in PubMed and EMBASE, followed by meta-analysis. Meta-analysis was performed using a random-effects model, with results presented as a pooled effect estimate with 95% confidence intervals (CIs). The quality of study (risk of bias and confounding) was assessed by 13 RTI questionnaires. Heterogeneity between studies and its possible sources were assessed by Egger test and meta-regression, respectively.Results: In all, 61 studies were identified and 29 were included in the meta-analysis. Based on JEM-based studies, there was 22% (pooled odds ratio =1.22; 95% CI 1.18–1.27) increased risk of COPD among those exposed to airborne pollutants arising from occupation. Comparatively, higher risk estimates were obtained for general populations JEMs (based on expert consensus) than workplace-based JEM were derived using measured exposure data (1.26; 1.20–1.33 vs 1.14; 1.10–1.19). Higher risk estimates were also obtained for self-reported exposure to VGDF than JEMs-based exposure to VGDF (1.91; 1.72–2.13 vs 1.10; 1.06–1.24). Dusts, particularly biological dusts (1.33; 1.17–1.51), had the highest risk estimates for COPD. Although the majority of occupational COPD studies focus on dusty environments, no difference in risk estimates was found for the common forms of occupational airborne pollutants.Conclusion: Our findings highlight the need to interpret previous studies with caution as self-reported exposure to VGDF may have overestimated the risk of occupational COPD. Keywords: COPD, occupation, airborne substances, job exposure matrices |
| Databáze: | OpenAIRE |
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