Gene-circuit therapy on the horizon: synthetic biology tools for engineered therapeutics
| Autor: | Rafał Krzysztoń, Gábor Balázsi, Julia Petreczky, Yiming Wan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Gene Circuits
Computer science Cell- and Tissue-Based Therapy Context (language use) Genetic Therapy Computational biology Functional system Article General Biochemistry Genetics and Molecular Biology Synthetic biology ComputingMethodologies_PATTERNRECOGNITION Insulin-Secreting Cells Humans Gene Regulatory Networks Synthetic Biology Gene |
| Zdroj: | Acta Biochim Pol |
| ISSN: | 1734-154X 0001-527X |
| DOI: | 10.18388/abp.2020_5744 |
| Popis: | Therapeutic genome modification requires precise control over the introduced therapeutic functions. Current approaches of gene and cell therapy fail to deliver such command and rely on semi-quantitative methods with limited influence on timing, contextuality and levels of transgene expression, and hence on therapeutic function. Synthetic biology offers new opportunities for quantitative functionality in designing therapeutic systems and their components. Here, we discuss synthetic biology tools in their therapeutic context, with examples of proof-of-principle and clinical applications of engineered synthetic biomolecules and higher-order functional systems, i.e. gene circuits. We also present the prospects of future development towards advanced gene-circuit therapy. |
| Databáze: | OpenAIRE |
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