The Use of Guided Tissue Regeneration Principles in Endodontic Surgery for Induced Chronic Periodontic-Endodontic Lesions: A Clinical, Radiographic, and Histologic Evaluation
| Autor: | Thomas von Arx, David L. Cochran, Daniel Buser, Robert K. Schenk, Pirkka V. Nummikoski, Steven K. Britain |
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| Rok vydání: | 2005 |
| Předmět: |
Mineral trioxide aggregate
medicine.medical_specialty Time Factors Retrograde Obturation Radiography medicine.medical_treatment Alveolar Bone Loss Bone Matrix Dentistry Pilot Projects Surgical Flaps Root Canal Filling Materials Dogs Absorbable Implants Periodontal Attachment Loss Alveolar Process Dental Pulp Necrosis medicine Animals Aluminum Compounds Dental Cementum business.industry Silicates Open flap debridement Apicoectomy General Engineering Membranes Artificial Oxides Buccal administration Calcium Compounds Root Canal Therapy Surgery Disease Models Animal Drug Combinations Endodontic surgery Treatment Outcome Guided Tissue Regeneration Periodontal Periodontics Collagen business Root Canal Preparation |
| Zdroj: | Journal of Periodontology. 76:450-460 |
| ISSN: | 1943-3670 0022-3492 |
| DOI: | 10.1902/jop.2005.76.3.450 |
| Popis: | Chronic periodontic-endodontic lesions are not uncommon in clinical practice and their regenerative capacity has long been questioned. However, there are no published studies investigating the application of guided tissue regeneration techniques in combination with endodontic surgery using an induced perio-endo defect model. This study evaluated the clinical, radiographic, and histologic outcomes of three surgical procedures used to treat induced perio-endo lesions.Pulpal necrosis was induced in foxhounds along with surgical removal of radicular buccal bone. After 4 weeks, chronic lesions were clinically and radiographically assessed. Treatment surgery consisted of apicoectomy, root canal instrumentation, and retrofilling with mineral trioxide aggregate. Teeth were then assigned to one of the following treatment groups: open flap debridement only (OFD), OFD with bioabsorbable porcine-derived collagen membrane (BG), or OFD with BG and anorganic bovine bone matrix (BO/BG). Clinical parameters and standardized radiographs were assessed at defect creation; treatment surgery; and at 1, 2, 4, and 6 months. Animals were sacrificed at 6 months and specimens prepared for histometric analysis.Clinical and radiographic conditions improved during the study period. Mean epithelial attachment was similar between all groups. Mean connective tissue attachment for groups OFD, BG, and BO/BG was 3.79 mm, 2.63 mm, and 1.75 mm, respectively, and mean radicular bone height was 2.16 mm, 3.24 mm, and 3.45 mm, respectively. Statistically significant increases in the amount of new cementum were observed in groups BG and BO/BG when compared with OFD (P0.05).Treatment of combined induced perio-endo lesions using bioabsorbable collagen membranes alone or in combination with anorganic bovine bone matrix resulted in increased amounts of bone, periodontal ligament, and significant increases in the amount of new cementum when compared to open flap debridement in a canine model. |
| Databáze: | OpenAIRE |
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