Colonic mesenchyme differentiates into smooth muscle before its colonization by vagal enteric neural crest-derived cells in the chick embryo
| Autor: | Norbert Chauvet, Annick Bourret, Pascal de Santa Barbara, Sandrine Faure |
|---|---|
| Přispěvatelé: | Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Mesoderm Pathology medicine.medical_specialty Histology Colon Mesenchyme [SDV]Life Sciences [q-bio] Population Mesenchymal cell differentiation Biology Pathology and Forensic Medicine 03 medical and health sciences symbols.namesake 0302 clinical medicine Smooth muscle medicine Animals education ComputingMilieux_MISCELLANEOUS Body Patterning education.field_of_study Stomach Neural crest Cell Differentiation Muscle Smooth Cell Biology Interstitial cell of Cajal Intestines 030104 developmental biology medicine.anatomical_structure Neural Crest symbols Chick embryo Enteric nervous system Endoderm 030217 neurology & neurosurgery |
| Zdroj: | Cell and Tissue Research Cell and Tissue Research, Springer Verlag, 2017, 368 (3), pp.503-511. ⟨10.1007/s00441-017-2577-0⟩ |
| ISSN: | 0302-766X 1432-0878 |
| DOI: | 10.1007/s00441-017-2577-0⟩ |
| Popis: | During development, the gastrointestinal (GI) tract arises from a primary tube composed of mesoderm and endoderm. The mesoderm gives rise to the digestive mesenchyme, which in turn differentiates into multiple tissues, namely the submucosa, the interstitial cells of Cajal and the smooth muscle cells (SMCs). Concomitant with these early patterning events, the primitive GI tract is colonized by vagal enteric neural crest-derived cells (vENCDCs), a population of cells that gives rise to the enteric nervous system, the intrinsic innervation of the GI tract. Reciprocal neuro-mesenchymal interactions are essential for the coordinated development of GI musculature. The aim of this study is to examine and compare the kinetics of mesenchymal cell differentiation into SMCs along the anterior-posterior axis to the pattern of vENCDCs migration using whole-mount in situ hybridization and paraffin section immunofluorescence analyses on chick embryonic GI tracts from E4-Stage 23 to E7-Stages 30-31. We confirmed that gastric and pre-umbilical intestine mesenchyme differentiation into SMCs occurs after vENCDCs colonization. However, we found that colonic and post-umbilical intestine mesenchyme differentiation occurs before vENCDCs colonization. These findings suggest that regional-specific mechanisms are involved in the mesenchyme differentiation into SMCs along the GI anterior-posterior axis. |
| Databáze: | OpenAIRE |
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