Functional results of exclusive interventional radiotherapy (brachytherapy) in the treatment of nasal vestibule carcinomas
| Autor: | Gaetano Paludetti, Valentina Lancellotta, Gian Carlo Mattiucci, Maria Antonietta Gambacorta, Francesco Bussu, Antonio Salvati, Giovanni Di Cintio, Vincenzo Valentini, Luca Tagliaferri, Giulio Cesare Passali, Eugenio De Corso, Jacopo Galli, Davide Rizzo |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Mucociliary clearance medicine.medical_treatment Brachytherapy External beam radiotherapy Mucociliary transport 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine medicine Nasal vestibule carcinoma Humans Radiology Nuclear Medicine and imaging Nose medicine.diagnostic_test business.industry Radiotherapy Dosage Olfaction Radiation therapy medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Vestibule Nasal cytology Carcinoma Squamous Cell Radiology Settore MED/31 - OTORINOLARINGOIATRIA Nasal Cavity Nasal vestibule Rhinomanometry business |
| Popis: | Surgery, external beam radiotherapy (EBRT), and interventional radiotherapy (IRT, BrachyTherapy BT) are the current therapeutic options for nose vestibule (NV) squamous cell carcinoma (SCC). In this article, we evaluate the nose functional parameters of patients affected by SCCs of the NV, primarily treated by interstitial IRT comparing them with healthy controls and with patients treated with intensity-modulated EBRT.Ten patients treated by using IRT (group 1), 10 healthy controls and eight patients treated by EBRT (group 2) on the region of the nose were submitted to clinical evaluation (with the NOSE scale score), rhinomanometry, olfactory testing, nasal citology, and evaluation of mucociliary clearance through saccharine test.No long-term skin or cartilaginous toxicity are recorded. The olfactometry threshold discrimination identification TDI is lower in EB group. The mean NOSE scale score was significantly higher in group 2 than in group 1 and healthy controls (p0.05). The distribution of cytologic patterns resulted significantly different as well. Patients treated by EB have a significantly impaired mucociliary clearance, with a mean time for the transport of the stained marker, which is more than double in the patients treated by EB than in those treated with IRT (p0.001).Nasal function and cytological findings are significantly better, substantially preserved, in patients treated by IRT than in those treated by EBRT, bringing new relevant evidence for the establishment of interstitial IRT as the new standard for the treatment of the primary lesion in cT1 and cT2 -Wang staging NV SCCs. |
| Databáze: | OpenAIRE |
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