Effects of Administration of Prostagrandin F2.ALPHA.-Analogue Fenprostalene on Canine Corpus Luteum and Subsequent Recurrence of Estrus and Fecundity
| Autor: | Eiichi Kawakami, Toshihiko Tsutsui, Tatsuya Hori, Takako Akikawa |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
endocrine system
medicine.medical_specialty Time Factors media_common.quotation_subject Alpha (ethology) Andrology Dogs Estrus Corpus Luteum Pregnancy Internal medicine Animals Medicine Ovulation Progesterone media_common Estrous cycle Dose-Response Relationship Drug General Veterinary business.industry Fecundity Peripheral blood Fertility Subsequent Recurrence Endocrinology Fenprostalene medicine.anatomical_structure Prostaglandins F Synthetic Female business Corpus luteum |
| Zdroj: | Journal of Veterinary Medical Science. 64:807-811 |
| ISSN: | 1347-7439 0916-7250 |
| DOI: | 10.1292/jvms.64.807 |
| Popis: | The effects of the long-acting prostagrandin F(2)(alpha)-analogue fenprostalene were investigated. Twenty-three female beagles (24 cases) 1-6 years of age were divided into 6 groups, and a dose of 5-150 microg/head of fenprostalene was subcutaneously administered at 25 days after ovulation to investigate its effects based on peripheral blood progesterone (P(4)) levels. The dogs were also examined for shortening of their estrous cycle after administration and fecundity after the recurrence of estrus. The results showed that the administration of 50 microg/head of fenprostalene or more reduced the levels of peripheral blood P(4) to about 1 ng/ml 2 days after administration, indicating early regression of the corpus luteum, and that the administration of these doses shortened the time to the subsequent estrus by a mean of about 80 days, and that conception rates were normal if estrus recurred about 2 months after fenprostalene administration or later. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|