CT guided 125iodine seed implantation for portal vein tumor thrombus in primary hepatocellular carcinoma
| Autor: | Fu Jun Zhang, De Chao Jiao, Pei Hong Wu, Nian Hua Zhang, Guang Feng Duan, Yue Xia Wu, Chuan Xing Li |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Carcinoma Hepatocellular medicine.medical_treatment Iodine Radioisotopes Carcinoma Medicine Humans Transcatheter arterial chemoembolization Aged Venous Thrombosis Radiotherapy business.industry Portal Vein Microwave ablation Biliary fistula Liver Neoplasms General Medicine Middle Aged medicine.disease Radiation therapy Treatment Outcome Pancreatic fistula Hepatocellular carcinoma Female Radiology Percutaneous ethanol injection business Tomography X-Ray Computed Follow-Up Studies |
| Zdroj: | Chinese medical journal. 121(23) |
| ISSN: | 2542-5641 |
| Popis: | Background This study evaluated the clinical application of CT guided (125)iodine implantation in patients with portal vein tumor thrombus in primary hepatocellular carcinoma. Methods The ten patients (9 males and 1 female, aged from 36 to 72 years) with portal vein tumor thrombus accompanying hepatocellular carcinoma had been treated with comprehensive therapy including surgery, transcatheter arterial chemoembolization, radiotherapy ablation, microwave ablation or percutaneous ethanol injection. The average diameter of each tumor thrombus was 21.5 mm x 30.5 mm. Seeds of 30 MBq (125)I were implanted 5 mm apart within the portal vein tumor thrombus. The follow-up after 4 months included enhanced spiral CT. Results CT screening of the tumours indicated that 4 out of 10 patients showed complete response to the therapy, 5 partial response and 1 stable disease. Adverse effects included aggravated abdominal dropsy and temporarily increased transaminase, which were controlled by medical management. Severe complications such as haemorrhage, biliary fistula, hepatic abscess, pancreatic fistula and hepatic function failure were not observed. Implanted seeds migrated to lung and left hepatic lobe in 1 case. Conclusion CT guided implantation of 125 iodine seeds, can effectively treat portal vein tumor thrombus accompanying hepatocellular carcinoma with minimal damage and few complications. |
| Databáze: | OpenAIRE |
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