Manganese intoxication: the cause of an inexplicable epileptic syndrome in a 3 year old child
| Autor: | Enrico Pira, Elena Herrero Hernandez, Laura Jarre, Patrizia Dassi, Gianluigi Discalzi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Physiology chemistry.chemical_element Urine Manganese Toxicology Central nervous system disease Epilepsy medicine Humans Brain magnetic resonance imaging Epileptic Syndrome Chelating Agents business.industry Manganese Poisoning General Neuroscience Electroencephalography Syndrome medicine.disease Surgery chemistry Child Preschool Toxicity Etiology business |
| Popis: | Excess manganese (Mn) can cause several neurotoxic effects, however only a few studies have reported epileptic syndromes related to manganese intoxication. We describe an epileptic syndrome due to manganese intoxication in a 3 year old male child. His blood manganese was elevated, but no other abnormal values or toxic substances were found in blood or urine. The electroencephalogram (EEG) showed a picture of progressive encephalopathy, while brain magnetic resonance was normal. The patient’s conditions rapidly worsened to epileptic status despite the use of antiepileptic drugs. Chelating treatment with CaNa 2 EDTA was initiated to remove excess manganese and promptly succeeded in reverting epileptic symptoms. Concurrently, manganese blood levels and electroencephalogram progressively normalized. Thereafter it has been possible to discontinue antiepileptic treatment, and the patient remains in excellent conditions without any treatment. |
| Databáze: | OpenAIRE |
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