A systematic review of factors that influence the acceptability of vaccines among Canadians
| Autor: | Shainoor J. Ismail, Lisa Hartling, Matthew Tunis, Kendra Hardy, Samantha Guitard, Kelsey Young, Allison Gates, Jennifer Pillay, Robin Featherstone, Tara MacGregor, Michelle Gates, Sholeh Rahman |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Canada Reminder Systems 030231 tropical medicine Population Psychological intervention Disease 03 medical and health sciences 0302 clinical medicine Intervention (counseling) Agency (sociology) medicine Humans 030212 general & internal medicine education Child education.field_of_study General Veterinary General Immunology and Microbiology business.industry Public health Vaccination Public Health Environmental and Occupational Health Rotavirus Vaccines Rotavirus vaccine Infectious Diseases Family medicine Molecular Medicine Immunization business |
| Zdroj: | Vaccine. 39(2) |
| ISSN: | 1873-2518 |
| Popis: | Background Canada's National Advisory Committee on Immunization (NACI) provides guidance on the use of vaccines in Canada. To support the expansion of its mandate to include considerations for vaccine acceptability when making recommendations, the NACI Secretariat developed a matrix of factors that influence acceptability. To inform and validate the matrix, we systematically reviewed evidence for factors that influence vaccine acceptability, and for interventions aimed at improving acceptability. Methods On 10–11 October 2018 we searched four bibliographic databases, the Theses Canada Portal, and ClinicalTrials.gov. Two reviewers agreed on the included studies. From each study, we extracted information about the participants, intervention or exposure, comparator, and relevant outcomes. Due to heterogeneity in the reported factors and acceptability indicators we synthesized the findings narratively. We appraised the certainty of evidence using GRADE. For each vaccine-preventable disease we populated a matrix of factors for which there was evidence of an influence on acceptability. Results One hundred studies (>1 million participants) contributed data relevant to the public, 16 (6191 participants) to healthcare providers, and three (84 participants) to policymakers. There were 43 intervention studies (~2 million participants). Across vaccines, we identified low certainty evidence for 70 factors relevant to the general population, 56 to high-risk groups, and 30 to healthcare providers. The perceived safety and importance of the vaccine, vaccination history, and receiving a recommendation from a healthcare provider were common influential factors. We found low certainty evidence that reminders for childhood vaccines and policies or delivery models for rotavirus vaccines could improve uptake and coverage. Evidence for other interventions was of very low certainty. Conclusions The NACI vaccine acceptability matrix is useful for categorizing acceptability factors for the general public. Reminder systems may improve the uptake of childhood vaccines. Policies that make the rotavirus vaccine universally available and easily accessible may improve coverage. Funding This systematic review was completed under contract to the Public Health Agency of Canada, Contract #4600001536. |
| Databáze: | OpenAIRE |
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