Transcriptional regulation of the caspofungin-induced cell wall damage response in Candida albicans

Autor: Jason M. Rauceo, Deepika Gunasekaran, Clarissa J. Nobile, Mélanie A. C. Ikeh, Marienela Y. Heredia
Rok vydání: 2020
Předmět:
Transcription
Genetic
Antifungal drug
chemistry.chemical_compound
Caspofungin
Cell Wall
Gene Expression Regulation
Fungal
Candida albicans
Transcriptional regulation
2.2 Factors relating to the physical environment
2.1 Biological and endogenous factors
Aetiology
Transcription networks
0303 health sciences
biology
030302 biochemistry & molecular biology
General Medicine
Corpus albicans
Cell biology
Fungal
Infectious Diseases
Basic-Leucine Zipper Transcription Factors
Signal transduction
Transcription
Biotechnology
medicine.drug
Signal Transduction
Saccharomyces cerevisiae Proteins
Stress signaling
Echinocandin
MADS Domain Proteins
Saccharomyces cerevisiae
Microbiology
Article
03 medical and health sciences
Genetic
Genetics
medicine
Humans
Transcription factor
030304 developmental biology
Antifungals
Fungi
Transcription circuits
biology.organism_classification
bacterial infections and mycoses
Repressor Proteins
Gene Expression Regulation
chemistry
Transcription Factors
Zdroj: Curr Genet
Current genetics, vol 66, iss 6
ISSN: 1432-0983
Popis: The human fungal pathogen Candida albicans maintains pathogenic and commensal states primarily through cell wall functions. The echinocandin antifungal drug caspofungin inhibits cell wall synthesis and is widely used in treating disseminated candidiasis. Signaling pathways are critical in coordinating the adaptive response to cell wall damage (CWD). C. albicans executes a robust transcriptional program following caspofungin-induced CWD. A comprehensive analysis of signaling pathways at the transcriptional level facilitates the identification of prospective genes for functional characterization and propels the development of novel antifungal interventions. This review article focuses on the molecular functions and signaling crosstalk of the C. albicans transcription factors Sko1, Rlm1, and Cas5 in caspofungin-induced CWD signaling.
Databáze: OpenAIRE
Externí odkaz: