Formal [4+3] Epoxide Cascade Reaction via a Complementary Ambiphilic Pairing Strategy

Autor:	Thiwanka Bandara Samarakoon, Alan Rolfe, Paul R. Hanson
Rok vydání:	2010
Předmět:	Sulfonamides Molecular Structure Thiazepines Chemistry Stereochemistry Organic Chemistry Epoxide Stereoisomerism Biochemistry Article chemistry.chemical_compound Cascade reaction Cyclization Nucleophilic aromatic substitution Pairing Epoxy Compounds Physical and Theoretical Chemistry
Zdroj:	Organic Letters. 12:1216-1219
ISSN:	1523-7052 1523-7060
Popis:	A formal [4+3] epoxide cascade protocol utilizing ambiphilic sulfonamides and a variety of epoxides (masked ambiphiles) has been developed for the generation of benzothiaoxazepine-1,1'-dioxides and oxathiazepine-1,1'-dioxides. This protocol combines an epoxide ring-opening with either an S(N)Ar or oxa-Michael cyclization pathway.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74ecdb4f91027c5b3ff274d510e959d7 https://doi.org/10.1021/ol100035e Zobrazit plný text záznamu