Altered microRNAs expression levels of sperm and seminal plasma in patients with infertile ejaculates compared with normozoospermic males
| Autor: | Zsuzsanna Molnár, Balint L. Balint, Emese Varga Tóthné, Istvan Balogh, Attila Jakab, Attila Mokánszki, Béla Bodnár |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Infertility 030209 endocrinology & metabolism Klinikai orvostudományok Andrology Young Adult 03 medical and health sciences 0302 clinical medicine Semen microRNA medicine Humans In patient Regulation of gene expression 030219 obstetrics & reproductive medicine business.industry fungi food and beverages Obstetrics and Gynecology Unprotected intercourse Oligospermia Orvostudományok General Medicine medicine.disease Spermatozoa Sperm MicroRNAs Reproductive Medicine Asthenozoospermia Case-Control Studies business |
| Zdroj: | Human Fertility. 23:246-255 |
| ISSN: | 1742-8149 1464-7273 |
| Popis: | Approximately 15% of couples are unable to conceive after one year of unprotected intercourse. Because sperm can be accessed with ease, it is reasonable to search for non-invasive biomarkers in semen. MicroRNAs are a family of short single-stranded non-coding RNA molecules that are capable of regulating gene expression and causing mRNA degradation. We studied the most common 11 spermatogenesis-related microRNAs expression levels in sperm and seminal plasma from patients with oligozoospermic or asthenozoospermic ejaculates, and in men with normozoospermic ejaculates. Five of these miRNAs were significantly upregulated and three were downregulated in infertile males compared to men with normozoospermic ejaculates. A statistically significant negative correlation was found between the sperm concentration and several microRNA expression level (let-7a, miR-7-1-3p, miR-141, miR-200a, and miR-429 |
| Databáze: | OpenAIRE |
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