Drug-eluting versus bare metal stents in patients with st-segment-elevation myocardial infarction: eight-month follow-up in the Drug Elution and Distal Protection in Acute Myocardial Infarction (DEDICATION) trial
| Autor: | Henning, Kelbaek, Leif, Thuesen, Steffen, Helqvist, Peter, Clemmensen, Lene, Kløvgaard, Anne, Kaltoft, Bente, Andersen, Helle, Thuesen, Thomas, Engstrøm, Hans E, Bøtker, Kari, Saunamäki, Lars R, Krusell, Erik, Jørgensen, Hans-Henrik T, Hansen, Evald H, Christiansen, Jan, Ravkilde, Lars, Køber, Klaus F, Kofoed, Christian J, Terkelsen, Jens F, Lassen, S D, Kristensen |
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| Rok vydání: | 2008 |
| Předmět: |
Bare-metal stent
medicine.medical_specialty medicine.medical_treatment Myocardial Infarction Coronary Artery Disease Coronary Angiography Coronary artery disease Restenosis Physiology (medical) Angioplasty Internal medicine medicine Humans Angioplasty Transluminal Percutaneous Coronary Myocardial infarction Angioplasty Balloon Coronary Cell Proliferation business.industry ST elevation Coronary Stenosis Stent Percutaneous coronary intervention Drug-Eluting Stents Thrombosis medicine.disease Surgery Death Treatment Outcome Cardiology Stents Cardiology and Cardiovascular Medicine business Tunica Intima Follow-Up Studies |
| Zdroj: | Kelbaek, H, Thuesen, L, Helqvist, S, Clemmensen, P, Kløvgaard, L, Kaltoft, A, Andersen, B, Thuesen, H H H, Engstrøm, T, Bøtker, H E, Saunamäki, K, Krusell, L R, Jørgensen, E, Hansen, H-H T, Christiansen, E H, Ravkilde, J, Køber, L, Kofoed, K F, Terkelsen, C J, Lassen, J F & DEDICATION Investigators 2008, ' Drug-eluting versus bare metal stents in patients with st-segment-elevation myocardial infarction: eight-month follow-up in the Drug Elution and Distal Protection in Acute Myocardial Infarction (DEDICATION) trial ', Circulation, vol. 118, no. 11, pp. 1155-62 . https://doi.org/10.1161/CIRCULATIONAHA.107.758698 |
| ISSN: | 1524-4539 |
| DOI: | 10.1161/CIRCULATIONAHA.107.758698 |
| Popis: | Background— Implantation of drug-eluting stents (DES) limits the rate of coronary restenosis in most patients with coronary artery disease, but data are scarce with regard to their use in patients with ST-segment–elevation myocardial infarction and in connection with distal protection of the microvascular perfusion during primary percutaneous coronary intervention. Methods and Results— We randomly assigned 626 patients referred within 12 hours from symptom onset of an ST-elevation myocardial infarction to have a DES or a bare metal stent implanted in the infarct-related lesion with or without distal protection during primary percutaneous coronary intervention. Quantitative coronary angiography was performed during the index treatment and 8 months later. The primary end point was loss of the lumen diameter in the infarct-related lesion induced by neointimal proliferation. Patients were comparable with regard to baseline demographic and angiographic characteristics. The mean late lumen loss was significantly lower in patients treated with a DES (0.06 mm; SD, 0.66 mm) than in patients who had a bare metal stent implanted (0.47 mm; SD, 0.69 mm; P P =0.03). Cardiac death occurred in 4.2% and 1.6% of the patients ( P =0.09) and stent thrombosis occurred in 2.0% and 2.6% ( P =0.72), respectively. Conclusion— Implantation of DES improves the angiographic outcome and need for repeat revascularization without increasing the short-term risk of stent thrombosis but has a tendency to increase cardiac death in patients with ST-segment–elevation myocardial infarction. |
| Databáze: | OpenAIRE |
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