Aerosolized Bexarotene Inhibits Lung Tumorigenesis without Increasing Plasma Triglyceride and Cholesterol Levels in Mice
| Autor: | Jing Pan, Ronald A. Lubet, Pengyuan Liu, Ming You, Da-Ren Chen, Jingjie Zhang, Ruth Chen, Qi Zhang, Yian Wang |
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| Rok vydání: | 2011 |
| Předmět: |
Agonist
Cancer Research medicine.medical_specialty Lung Neoplasms Tetrahydronaphthalenes Mice Inbred A medicine.drug_class Apoptosis Pharmacology medicine.disease_cause Immunoenzyme Techniques Mice chemistry.chemical_compound In vivo Internal medicine Administration Inhalation medicine Animals Anticarcinogenic Agents Lung cancer Triglycerides Cell Proliferation Bexarotene Cholesterol business.industry Hypertriglyceridemia respiratory system medicine.disease Endocrinology Oncology chemistry Female business Carcinogenesis medicine.drug |
| Zdroj: | Cancer Prevention Research. 4:270-276 |
| ISSN: | 1940-6215 1940-6207 |
| Popis: | Prior studies have shown the retinoid X receptor (RXR) agonist bexarotene has preventive efficacy in rodent models of mammary and lung tumorigenesis albeit causing hypertriglyceridemia and hypercholesterolemia. We reasoned that bexarotene delivered by inhalation may provide sufficient dose directly to the respiratory tract to achieve efficacy while avoiding these side effects. In this study, the chemopreventive activity of aerosolized bexarotene was investigated in the benzo(a)pyrene [B(a)P]-induced mouse lung tumor model as assessed by tumor multiplicity and tumor load. Aerosolized bexarotene significantly decreased tumor multiplicity and tumor load by 43% and 74%, respectively. Our data showed that bexarotene can both inhibit proliferation and promote apoptosis in vivo. Our data also show that aerosolized bexarotene did not increase plasma total cholesterol and triglyceride level compared with diet group. These results indicate that aerosolization may be a safe and effective route of administering bexarotene for chemoprevention of lung cancer. Cancer Prev Res; 4(2); 270–6. ©2010 AACR. |
| Databáze: | OpenAIRE |
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