Strigolactone analogs act as new anti-cancer agents in inhibition of breast cancer in xenograft model
| Autor: | Dana Laufer, Shani Ben-Harosh, Michael D. Johnson, Cristina Prandi, Hinanit Koltai, Julia Shaknof, Eduard Belausov, Ariel Bier, Ola Genin, Emma Artuso, Yoram Kapulnik, Christopher F Grivas, Ronit I. Yarden, Einav Mayzlish-Gati, Oshrat Levi, Isam Khalaila, Amiram Sananes, Mark Pines |
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| Rok vydání: | 2015 |
| Předmět: |
Cancer Research
Paclitaxel Cell Survival Mice Nude Strigolactone Antineoplastic Agents Breast Neoplasms cell motility plant hormone Biology Lactones chemistry.chemical_compound breast cancer Breast cancer Cell Movement Cell Line Tumor medicine Animals Humans strigolactone xenograft Pharmacology Mice Inbred BALB C Mice Inbred ICR integumentary system Melanoma Cancer cell motility microtubule Oncology Molecular Medicine Drug Synergism medicine.disease Xenograft Model Antitumor Assays Research Papers Molecular medicine Tumor Burden chemistry Apoptosis Immunology Cancer research Osteosarcoma Female Heterocyclic Compounds 3-Ring microtubule |
| Zdroj: | Cancer Biology & Therapy. 16:1682-1688 |
| ISSN: | 1555-8576 1538-4047 |
| DOI: | 10.1080/15384047.2015.1070982 |
| Popis: | Strigolactones (SLs) are a novel class of plant hormones. Previously, we found that analogs of SLs induce growth arrest and apoptosis in breast cancer cell lines. These compounds also inhibited the growth of breast cancer stem cell enriched-mammospheres with increased potency. Furthermore, strigolactone analogs inhibited growth and survival of colon, lung, prostate, melanoma, osteosarcoma and leukemia cancer cell lines. To further examine the anti-cancer activity of SLs in vivo, we have examined their effects on growth and viability of MDA-MB-231 tumor xenografts model either alone or in combination with paclitaxel. We show that strigolactone act as new anti-cancer agents in inhibition of breast cancer in xenograft model. In addition we show that SLs affect the integrity of the microtubule network and therefore may inhibit the migratory phenotype of the highly invasive breast cancer cell lines that were examined. |
| Databáze: | OpenAIRE |
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