Altered hypothalamus-pituitary-adrenal axis function: A relevant factor in the comorbidity of atopic eczema and attention deficit/hyperactivity disorder?
| Autor: | Angela Rösen-Wolff, Angelika Buske-Kirschbaum, Franziska Plessow, Falko Tesch, Hella Luksch, Jochen Schmitt, Katharina Trikojat, Veit Roessner |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Hypothalamo-Hypophyseal System endocrine system medicine.medical_specialty Cortisol awakening response Hydrocortisone Endocrinology Diabetes and Metabolism Comorbidity Impulsivity Dermatitis Atopic 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine mental disorders Epidemiology medicine Trier social stress test Humans Attention deficit hyperactivity disorder Child Biological Psychiatry Psychological Tests Endocrine and Autonomic Systems business.industry medicine.disease Pathophysiology 030227 psychiatry Psychiatry and Mental health Attention Deficit Disorder with Hyperactivity Hypothalamus Female medicine.symptom business Stress Psychological hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery |
| Zdroj: | Psychoneuroendocrinology. 105:178-186 |
| ISSN: | 0306-4530 |
| DOI: | 10.1016/j.psyneuen.2018.12.005 |
| Popis: | Epidemiological data show a significant association between childhood atopic eczema (AE) and an increased risk to develop attention deficit/hyperactivity disorder (ADHD). However, the underlying mechanisms of the comorbidity of AE and ADHD are mostly unknown. We investigated whether alterations of hypothalamus-pituitary-adrenal (HPA) axis function represent a shared feature of AE and ADHD potentiating AE-ADHD comorbidity. Children aged 6–12 years with AE, ADHD, or comorbid AE + ADHD and healthy control (HC) children were examined cross-sectionally (N = 145). To evaluate HPA axis function, salivary cortisol in response to psychosocial stress (Trier Social Stress Test for Children, TSST-C), after awakening (cortisol awakening response, CAR), and throughout the day (short diurnal profile) and hair cortisol capturing long-term HPA axis activity were assessed. Quantile regression analyses showed an attenuated cortisol response (% maximum change) to the TSST-C in children with ADHD compared to HC. A diminished cortisol response to acute stress was also observed in the comorbid AE + ADHD group, in which the reduction was numerically even more pronounced. Contrary to our previous findings, no alteration of the cortisol response to the TSST-C was observed in children with AE. However, in children with AE, increased ADHD-like behavior (i.e., inattention, impulsivity, and overall ADHD symptom severity) was associated with a reduced HPA axis response to acute stress. No such associations were observed in children without AE. Groups did not differ in CAR, short diurnal profile, and hair cortisol. These findings underscore the potential relevance of HPA axis function in the pathophysiology of AE and ADHD with emphasis on stress reactivity. Additional studies are required to further explore the separate and joint role of the HPA axis in the pathophysiology of AE and ADHD. |
| Databáze: | OpenAIRE |
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