Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918

Autor:	Robert Newman, Benjamin G. Tehan, J.D. Brown, Richard Mould, Alicia P. Higueruelo, K.A. Bennett, O'brien Michael Alistair, Flavia Autore, Cliona MacSweeney, Heather Currinn, Cheryl A. Brighton, Lisa A. Stott, Steve P. Watson
Rok vydání:	2021
Předmět:	0301 basic medicine GPR52 Science (General) medicine.medical_treatment Pharmacology 03 medical and health sciences chemistry.chemical_compound Q1-390 0302 clinical medicine medicine Inverse agonist Cannabidiol Orphan receptor H1-99 O-1918 Multidisciplinary Receptor interaction Social sciences (General) 030104 developmental biology chemistry CNS PHARMACOLOGY CBD Cannabinoid Orphan G-Protein Coupled Receptor 030217 neurology & neurosurgery medicine.drug Research Article
Zdroj:	Heliyon Heliyon, Vol 7, Iss 6, Pp e07201-(2021)
ISSN:	2405-8440
Popis:	The identification of cannabinoid ligands Cannabidiol and O-1918 as inverse agonists of the orphan receptor GPR52 is reported. Detailed characterisation of GPR52 pharmacology and modelling of the proposed receptor interaction is described. The identification of a novel and further CNS pharmacology for the polypharmacological agent and marketed drug Cannabidiol is noteworthy. GPR52, Inverse agonist, Cannabidiol, CBD, O-1918.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74e712b64596b5eaa25e6dd34e58553b https://pubmed.ncbi.nlm.nih.gov/34189291 Zobrazit plný text záznamu