Identification of Rabbit Antibodies Directed against Candida albicans
| Autor: | F. P. Inman, Nancy M. Matthews |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
Globulin
chemical and pharmacologic phenomena Immunoelectrophoresis Antibodies General Biochemistry Genetics and Molecular Biology Microbiology Antigen-Antibody Reactions Agglutinin Antigen Cell Wall Agglutination Tests medicine Animals Candida albicans Candida Mannan biology medicine.diagnostic_test Chemistry Immune Sera Gamma globulin biology.organism_classification Antibody Formation biology.protein Rabbits gamma-Globulins Antibody |
| Zdroj: | Experimental Biology and Medicine. 128:387-392 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-128-33019 |
| Popis: | SummaryThe nature of antibody globulins produced by rabbits immunized with heat-killed Candida albicans was investigated. Most of the antibodies were directed against a cell wall antigen rich in mannan. The agglutinin activity of immune serum, purified IgG, and a preparation highly enriched in IgM could be removed by absorption with mannan. In addition, when the IgM-containing preparation was reduced with 2-ME and alkylated, antibody activity was lost. We concluded that the rabbit makes antibodies of the IgG and IgM classes in response to intravenous injections of killed Candida albicans. |
| Databáze: | OpenAIRE |
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