Polycyclic Polyprenylated Acylphloroglucinol Congeners from Hypericum scabrum
| Autor: | Wan Gao, Wei-Zhen Hou, Jun Zhao, Fang Xu, Li Li, Hua Sun, Jian-Guo Xing, Ying Peng, Xiao-Liang Wang, Teng-Fei Ji, Zheng-Yi Gu |
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| Rok vydání: | 2016 |
| Předmět: |
Plant Components
Circular dichroism Stereochemistry Phloroglucinol Pharmaceutical Science HL-60 Cells 01 natural sciences Analytical Chemistry Inhibitory Concentration 50 chemistry.chemical_compound Drug Discovery Humans Inhibitory concentration 50 Organic chemistry Nuclear Magnetic Resonance Biomolecular Pharmacology Molecular Structure biology 010405 organic chemistry Organic Chemistry Hep G2 Cells Plant Components Aerial biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry Complementary and alternative medicine chemistry Hepg2 cells Molecular Medicine Hypericum scabrum Hypericum Drugs Chinese Herbal |
| Zdroj: | Journal of Natural Products. 79:1538-1547 |
| ISSN: | 1520-6025 0163-3864 |
| Popis: | Twenty polycyclic polyprenylated acylphloroglucinols (PPAPs), including the new compounds hyperscabrones A-I (1-9), were isolated from the air-dried aerial parts of Hypericum scabrum. These compounds comprise seven different structural types. All structures were determined by NMR spectroscopic methods and both experimental and calculated electronic circular dichroism (ECD) spectra. The evaluation of their neuroprotective effects on glutamate-induced toxicity in SK-N-SH cells showed that compounds 4-7 exhibited significant neuroprotection at 10 μM. Additionally, compounds 3, 4, 7, and 9 showed moderate hepatoprotective activities against paracetamol-induced HepG2 cell damage at 10 μM. |
| Databáze: | OpenAIRE |
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