Amelioration of virulentBabesia bovisinfection in calves by administration of the nitric oxide synthase inhibitor aminoguanidine
| Autor: | Bowden Jm, K.R. Gale, Matheson J, Waltisbuhl Dj, G. Leatch, William T. Jorgensen, Zakrzewski H, East Ij |
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| Rok vydání: | 1998 |
| Předmět: |
Fever
Anemia Immunology Cattle Diseases Nitric Oxide Synthase Type II Virulence Parasitemia In Vitro Techniques Nitric Oxide Guanidines Nitric oxide chemistry.chemical_compound Babesiosis medicine Animals Parasite hosting Enzyme Inhibitors biology Babesia bovis biology.organism_classification medicine.disease Virology Nitric oxide synthase chemistry biology.protein Cattle Parasitology Nitric Oxide Synthase |
| Zdroj: | Parasite Immunology. 20:441-445 |
| ISSN: | 1365-3024 0141-9838 |
| Popis: | Calves undergoing initial infection with a virulent strain of the haemoprotozoan parasite Babesia bovis were treated with aminoguanidine (AG), an inhibitor of the inducible form of nitric oxide synthase (iNOS). The mean maximum parasitaemia of the AG treated calves was significantly lower than that of the control cattle. In addition, the febrile response and decrease in packed cell volume (PCV) observed during acute infection were significantly ameliorated in the AG treated cattle relative to the controls. However, AG had no effect on the multiplication of B. bovis in the microaerophilous stationary-phase (MASP) in-vitro culture system. These results provide evidence of a role for nitric oxide (NO) produced in response to acute infection in the pathology of bovine babesiosis. |
| Databáze: | OpenAIRE |
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