Unusual Naphthoquinone Derivatives from the Twigs of Avicennia marina
| Autor: | Hongzheng Fu, Isabel Sattler, Hans-Martin Dahse, Wenhan Lin, Xueshi Huang, Ute Moellmann, Susanne Grabley, Li Han |
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| Rok vydání: | 2007 |
| Předmět: |
Stereochemistry
Chemical structure Pharmaceutical Science Pharmacognosy Analytical Chemistry Mice Structure-Activity Relationship chemistry.chemical_compound Drug Discovery Animals Humans Antibacterial agent Pharmacology Plants Medicinal Molecular Structure Plant Stems biology Verbenaceae Organic Chemistry Biological activity biology.organism_classification Antineoplastic Agents Phytogenic Naphthoquinone Anti-Bacterial Agents Quinone Complementary and alternative medicine chemistry Avicennia marina Molecular Medicine Avicennia Drug Screening Assays Antitumor Drugs Chinese Herbal Naphthoquinones |
| Zdroj: | Journal of Natural Products. 70:923-927 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np060587g |
| Popis: | In a continuing search for novel bioactive compounds from marine mangrove plants, seven new naphthoquinone derivatives were isolated from Avicennia marina, namely, avicennone A (1), avicennone B (2), avicennone C (3), avicennone D (4), avicenone E (5), avicennone F (6), and avicennone G (7), along with the known compounds avicequinone A (8), stenocarpoquinone B (9), avicequinone C (10), avicenol A (11), and avicenol C (12). The chemical structures of 1-7 were elucidated by spectroscopic methods. Compounds 8-10, and a mixture of 4 and 5, which all contain a 4,9-dione group, showed strong antiproliferative and moderate cytotoxic activities, as well as antibacterial effects. |
| Databáze: | OpenAIRE |
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