Effect of nutritive and non-nutritive sweeteners on hemodynamic responses to acute stress: a randomized crossover trial in healthy women
| Autor: | Robin Rosset, Camille Crézé, Luc Tappy, Philippe Schneiter, Jérémy Cros, Lucie Bidlingmeyer, Nathalie Stefanoni, Kevin Seyssel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Non-Nutritive Sweeteners
medicine.medical_specialty Cardiac output Mean arterial pressure Health Status Endocrinology Diabetes and Metabolism Hemodynamics Blood Pressure 01 natural sciences Article Beverages Young Adult 03 medical and health sciences 0302 clinical medicine Dietary Sucrose Stress Physiological Internal medicine Heart rate Internal Medicine medicine Humans Chronic stress Obesity lcsh:RC620-627 Cross-Over Studies business.industry 010401 analytical chemistry Crossover study Healthy Volunteers 3. Good health 0104 chemical sciences lcsh:Nutritional diseases. Deficiency diseases Cardiovascular diseases Blood pressure medicine.anatomical_structure Cardiology Vascular resistance Female Vascular Resistance business Nutritive Sweeteners Nutritive Value Stress Psychological 030217 neurology & neurosurgery |
| Zdroj: | Nutrition & Diabetes, Vol 10, Iss 1, Pp 1-8 (2020) Nutrition & Diabetes Nutrition & diabetes, vol. 10, no. 1, pp. 1 |
| ISSN: | 2044-4052 |
| DOI: | 10.1038/s41387-019-0104-y |
| Popis: | Background The mechanisms by which chronic stress increases the risk of non-communicable diseases remain poorly understood. On one hand, chronic stress may increase systemic vascular resistance (SVR) and blood pressure, which may lead to blood vessels injury and altered myocardial perfusion. On the other hand, chronic stress may promote the overconsumption of sugar-containing foods and favor obesity. There is indeed evidence that sweet foods are preferentially consumed to alleviate stress responses. The effects of nutritive and non-nutritive sweeteners (NNS) on hemodynamic stress responses remain however largely unknown. Objective/design This study aimed at comparing the effects of sucrose-containing and NNS-containing drinks, as compared to unsweetened water, on hemodynamic responses to acute stress in twelve healthy female subjects. Acute stress responses were elicited by a 30-min mental stress (5-min Stroop’s test alternated with 5-min mental arithmetic) and a 3-min cold pressure test (CPT), each preceded by a resting baseline period. Hemodynamic stress responses were investigated by the repeated measurement of mean arterial pressure and the continuous monitoring of cardiac output by thoracic electrical bioimpedance measurement. SVR was selected as a primary outcome because it is a sensitive measure of hemodynamic responses to acute stress procedures. Results With all three drinks, SVR were not changed with mental stress (P = 0.437), but were increased with CPT (P = 0.045). Both mental stress and CPT increased mean arterial pressure and heart rate (all P P P = 0.252). No significant differences in hemodynamic responses were observed between water, sucrose and NNS (stress × condition, all P > 0.05). Conclusions These results demonstrate that sucrose and NNS do not alter hemodynamic responses to two different standardized acute stress protocols. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|