Synthesis and anti-mycobacterial activity of (E)-N'-(monosubstituted-benzylidene)isonicotinohydrazide derivatives
| Autor: | Maria das Graças Henriques, Marcus Vinícius Nora de Souza, Monica Amado Peralta, Thatyana R. A. Vasconcelos, Maria C.S. Lourenço, Marcelle de Lima Ferreira |
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| Rok vydání: | 2007 |
| Předmět: |
Pharmacology
Magnetic Resonance Spectroscopy biology Spectrophotometry Infrared Chemistry Stereochemistry Organic Chemistry Isoniazid Antitubercular Agents Biological activity General Medicine Mycobacterium tuberculosis biology.organism_classification Chemical synthesis Minimum inhibitory concentration Hydrazines Drug Discovery medicine Antibacterial activity Rifampicin medicine.drug Antibacterial agent |
| Zdroj: | European journal of medicinal chemistry. 43(6) |
| ISSN: | 0223-5234 |
| Popis: | A series of 22 (E)-N'-(monosubstituted-benzylidene)isonicotinohydrazide derivatives have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H(37)Rv using Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC) in mug/mL. Compounds 2f, 2g, 2j, 2k and 2q exhibited a significant activity (0.31-0.62 microg/mL) when compared with first line drugs such as isoniazid (INH) and rifampicin (RIP) and could be a good starting point to develop new lead compounds in the fight against multi-drug resistant tuberculosis. |
| Databáze: | OpenAIRE |
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