Fecal Microbiota Transplant in Two Ulcerative Colitis Pediatric Cases: Gut Microbiota and Clinical Course Correlations
| Autor: | Quagliariello, A., Del Chierico, F., Reddel, S., Russo, A., Muda, A. O., D'Argenio, P., Angelino, G., Romeo, E. F., Dall'Oglio, L., De Angelis, P., Putignani, L., Bernaschi, P., Faraci, S., Finocchi, A., Foglietta, G., Gargiullo, L., Martino, S., Marucci, G., Merli, P., Pane, S., Rea, F., Torre, G., Torroni, F., Nobili, V. |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty Gut flora Microbiology Gastroenterology Inflammatory bowel disease 03 medical and health sciences 0302 clinical medicine Collinsella aerofaciens Virology Internal medicine Fecal microbiota transplantation (FMT) Gut bacterial ecology Gut microbiota Inflammatory bowel disease (IBD) Pediatric Ulcerative Colitis (UC) Medicine lcsh:QH301-705.5 gut microbiota biology fecal microbiota transplantation (FMT) business.industry Brief Report Clinical course Fecal bacteriotherapy biology.organism_classification medicine.disease Parabacteroides Ulcerative colitis inflammatory bowel disease (IBD) 030104 developmental biology lcsh:Biology (General) 030211 gastroenterology & hepatology Bacteroides business gut bacterial ecology |
| Zdroj: | Microorganisms Microorganisms, Vol 8, Iss 1486, p 1486 (2020) |
| ISSN: | 2076-2607 |
| DOI: | 10.3390/microorganisms8101486 |
| Popis: | Fecal microbiota transplantation (FMT) is a promising strategy in the management of inflammatory bowel disease (IBD). The clinical effects of this practice are still largely unknown and unpredictable. In this study, two children affected by mild and moderate ulcerative colitis (UC), were pre- and post-FMT monitored for clinical conditions and gut bacterial ecology. Microbiota profiling relied on receipts’ time-point profiles, donors and control cohorts’ baseline descriptions. After FMT, the improvement of clinical conditions was recorded for both patients. After 12 months, the mild UC patient was in clinical remission, while the moderate UC patient, after 12 weeks, had a clinical worsening. Ecological analyses highlighted an increase in microbiota richness and phylogenetic distance after FMT. This increase was mainly due to Collinsella aerofaciens and Eubacterium biforme, inherited by respective donors. Moreover, a decrease of Proteus and Blautia producta, and the increment of Parabacteroides, Mogibacteriaceae, Bacteroides eggerthi, Bacteroides plebeius, Ruminococcus bromii, and BBacteroidesovatus were associated with remission of the patient’s condition. FMT results in a long-term response in mild UC, while in the moderate form there is probably need for multiple FMT administrations. FMT leads to a decrease in potential pathogens and an increase in microorganisms correlated to remission status. |
| Databáze: | OpenAIRE |
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