IgE-activated mast cells enhance TLR4-mediated antigen-specific CD4+ T cell responses
| Autor: | Robin L. Baudier, Binh L. Phong, David L. Bauer, Shaina J. D’Souza, James B. McLachlan, Victoria E. Immethun, Eric L. Wu |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Multidisciplinary biology Chemistry Science Stimulation Acquired immune system Immunoglobulin E Mast cell Cell biology 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Immune system medicine.anatomical_structure Antigen TLR4 biology.protein medicine Medicine Histamine 030215 immunology |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-021-88956-4 |
| Popis: | Mast cells are potent mediators of allergy and asthma, yet their role in regulating adaptive immunity remains ambiguous. On the surface of mast cells, the crosslinking of IgE bound to FcεRI by a specific antigen recognized by that IgE triggers the release of immune mediators such as histamine and cytokines capable of activating other immune cells; however, little is known about the mast cell contribution to the induction of endogenous, antigen-specific CD4+ T cells. Here we examined the effects of specific mast cell activation in vivo on the initiation of an antigen-specific CD4+ T cell response. While CD4+ T cells were not enhanced by FcεRI stimulation alone, their activation was synergistically enhanced when FcεRI activation was combined with TLR4 stimulation. This enhanced activation was dependent on global TLR4 stimulation but appeared to be less dependent on mast cell expressed TLR4. This study provides important new evidence to support the role of mast cells as mediators of the antigen-specific adaptive immune response. |
| Databáze: | OpenAIRE |
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