High-Fat Diet Impacts on Tumor Development in the Gut
| Autor: | Louis Vermeulen, Milou S. van Driel, Sanne M. van Neerven |
|---|---|
| Přispěvatelé: | Center of Experimental and Molecular Medicine, Graduate School, CCA - Cancer biology and immunology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism |
| Rok vydání: | 2021 |
| Předmět: |
intestinal stem cells
tumor initiation 0301 basic medicine Cancer Research PPARs Colorectal cancer food and beverages colorectal cancer High fat diet Tumor initiation Biology medicine.disease 03 medical and health sciences high-fat diet 030104 developmental biology 0302 clinical medicine Oncology 030220 oncology & carcinogenesis Cancer research medicine Stem cell Intestinal tumors Beta oxidation |
| Zdroj: | Trends in cancer, 7(8), 664-665. Cell Press |
| ISSN: | 2405-8033 |
| DOI: | 10.1016/j.trecan.2021.06.005 |
| Popis: | A high-fat diet (HFD) directly acts on intestinal stem cells by increasing their numbers and proliferation, resulting in an elevated risk of developing colorectal cancer (CRC). In a recent study, Mana et al. revealed that HFD-mediated intestinal tumor formation can be reduced by inhibiting fatty acid oxidation. |
| Databáze: | OpenAIRE |
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