Factors associated with vasopressin release in exercising swine
| Autor: | Charles L Stebbins, F. F Y Hwang, J. D. Symons, M. D. McKirnan |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Vasopressin Captopril Epinephrine Swine Vasopressins Physiology Physical Exertion Lypressin Angiotensin-Converting Enzyme Inhibitors Blood Pressure Treadmill exercise Physical exercise Plasma renin activity Endocrine secretion Norepinephrine Physiology (medical) Internal medicine Renin medicine Animals Lysine vasopressin Chemistry Hemodynamics Angiotensin II Arginine Vasopressin Endocrinology Swine Miniature Female medicine.drug |
| Zdroj: | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 266:R118-R124 |
| ISSN: | 1522-1490 0363-6119 |
| DOI: | 10.1152/ajpregu.1994.266.1.r118 |
| Popis: | This study examined the effect of dynamic exercise on vasopressin release in the miniswine and factors that may elicit this response (n = 15). Thus lysine vasopressin (LVP), the catecholamines epinephrine and norepinephrine (EPI and NE), plasma renin activity (PRA), and plasma volume, Na+, and osmolality were measured before and during treadmill running at work intensities of 60, 80, and 100% of each swine's maximal heart rate reserve (HRR). LVP increased in a progressive manner similar to that of humans, ranging from 5.9 +/- 0.4 pg/ml before exercise to 30.1 +/- 4.5 pg/ml during maximal exercise. EPI, NE, and PRA [an index of angiotensin II (ANG II) activity] demonstrated a pattern of response comparable to LVP. Although these hormones can influence the release of LVP, only PRA displayed a strong correlation with LVP (r = 0.84). When ANG II synthesis was blocked (captopril, 1-3 mg/kg, intra-atrial injection) during exercise (80% HRR), plasma LVP was reduced from 9.9 +/- 0.6 to 7.5 +/- 0.6 pg/ml (P < 0.05). In addition, moderate-to-strong correlations were found between plasma concentrations of LVP and plasma osmolality (r = 0.79) and body temperature (r = 0.78). Plasma LVP also correlated with decreases in plasma volume (r = 0.84). These data suggest that the miniswine model is a good one for studying vasopressin effects during exercise and that ANG II appears to be a particularly strong stimulus for the release of this hormone. |
| Databáze: | OpenAIRE |
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