Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation?
| Autor: | Martin Kerschensteiner, Eike Gallmeier, Roland Kolbeck, Vivian Vargas Leal, Hartmut Wekerle, Ilse Bartke, Edmund Hoppe, Wolfgang E. F. Klinkert, Rosa-Laura Oropeza-Wekerle, Hans Lassmann, Christine Stadelmann, Thomas Misgeld, Reinhard Hohlfeld, Lüder Behrens |
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| Rok vydání: | 1999 |
| Předmět: |
Multiple Sclerosis
Transcription Genetic neurotrophic factors T cell T-Lymphocytes Immunology immunosuppressive therapy Inflammation Lymphocyte Activation Autoantigens Monocytes Myelin oligodendrocyte glycoprotein Myelin Immune system Neurotrophic factors medicine Immunology and Allergy Humans RNA Messenger Glycoproteins Brain-derived neurotrophic factor B-Lymphocytes Brain Diseases biology Brain-Derived Neurotrophic Factor autoimmunity neurodegeneration Myelin Basic Protein Neurodegenerative Diseases Myelin basic protein Oligodendroglia medicine.anatomical_structure nervous system biology.protein Encephalitis Brief Definitive Reports medicine.symptom |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 0022-1007 |
| Popis: | Brain-derived neurotrophic factor (BDNF) has potent effects on neuronal survival and plasticity during development and after injury. In the nervous system, neurons are considered the major cellular source of BDNF. We demonstrate here that in addition, activated human T cells, B cells, and monocytes secrete bioactive BDNF in vitro. Notably, in T helper (Th)1- and Th2-type CD4+ T cell lines specific for myelin autoantigens such as myelin basic protein or myelin oligodendrocyte glycoprotein, BDNF production is increased upon antigen stimulation. The BDNF secreted by immune cells is bioactive, as it supports neuronal survival in vitro. Using anti-BDNF monoclonal antibody and polyclonal antiserum, BDNF immunoreactivity is demonstrable in inflammatory infiltrates in the brain of patients with acute disseminated encephalitis and multiple sclerosis. The results raise the possibility that in the nervous system, inflammatory infiltrates have a neuroprotective effect, which may limit the success of nonselective immunotherapies. |
| Databáze: | OpenAIRE |
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