Relative Abundance of Proteins in Blood Plasma Samples from Patients with Chronic Cerebral Ischemia
| Autor: | Alexander А. Izotov, Valeria Yu. Kudryavtseva, Alexander I. Archakov, N B Teryaeva, A. T. Kopylov, Alexander Potapov, Elena A. Ponomarenko, Olga I. Kiseleva, Sergei Morozov, Anna L. Kaysheva |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Adolescent Proteome Ischemia Mass spectrometry Proteomics Brain Ischemia Brain ischemia 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Internal medicine Blood plasma medicine Humans Innate immune system Chemistry General Medicine Middle Aged medicine.disease 030104 developmental biology Endocrinology Female Biomarkers 030217 neurology & neurosurgery Homeostasis |
| Zdroj: | Journal of Molecular Neuroscience. 64:440-448 |
| ISSN: | 1559-1166 0895-8696 |
| DOI: | 10.1007/s12031-018-1040-3 |
| Popis: | A comparative protein profile analysis of 17 blood plasma samples from patients with ischemia and 20 samples from healthy volunteers was carried out using ultra-high resolution mass spectrometry. The analysis of measurements was performed using the proteomics search engine OMSSA. Normalized spectrum abundance factor (NSAF) in the biological samples was assessed using SearchGUI. The findings of mass spectrometry analysis of the protein composition of blood plasma samples demonstrate that the depleted samples are quite similar in protein composition and relative abundance of proteins. By comparing them with the control samples, we have found a small group of 44 proteins characteristic of the blood plasma samples from patients with chronic cerebral ischemia. These proteins contribute to the processes of homeostasis maintenance, including innate immune response unfolding, the response of a body to stress, and contribution to the blood clotting cascade. |
| Databáze: | OpenAIRE |
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