Transcranial laser stimulation: Mitochondrial and cerebrovascular effects in younger and older healthy adults
| Autor: | Emily C. Courtois, Francisco Gonzalez-Lima, Nusha Kheradbin, Celeste L. Saucedo, Meghan N. Kelley, Zachary S. Wade, Douglas W. Barrett |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Aging Adolescent Biophysics Prefrontal Cortex Brodmann area 10 Stimulation 050105 experimental psychology Cytochrome-c-oxidase lcsh:RC321-571 03 medical and health sciences Young Adult 0302 clinical medicine Internal medicine Transcranial infrared laser stimulation Medicine Deoxygenated Hemoglobin Humans 0501 psychology and cognitive sciences Prefrontal cortex lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Aged Aged 80 and over Cerebral Cortex Oxygenated Hemoglobin Spectroscopy Near-Infrared business.industry General Neuroscience Lasers 05 social sciences Oxygenation Photobiomodulation Middle Aged Brain aging Brain stimulation Cardiology Neurology (clinical) Hemoglobin business Cerebrovascular oxygenation 030217 neurology & neurosurgery |
| Zdroj: | Brain Stimulation, Vol 14, Iss 2, Pp 440-449 (2021) |
| ISSN: | 1876-4754 |
| Popis: | Background Transcranial laser stimulation is a novel method of noninvasive brain stimulation found safe and effective for improving prefrontal cortex neurocognitive functions in healthy young adults. This method is different from electric and magnetic stimulation because it causes the photonic oxidation of cytochrome-c-oxidase, the rate-limiting enzyme for oxygen consumption and the major intracellular acceptor of photons from near-infrared light. This photobiomodulation effect promotes mitochondrial respiration, cerebrovascular oxygenation and neurocognitive function. Pilot studies suggest that transcranial photobiomodulation may also induce beneficial effects in aging individuals. Objectives Randomized, sham-controlled study to test photobiomodulation effects caused by laser stimulation on cytochrome-c-oxidase oxidation and hemoglobin oxygenation in the prefrontal cortex of 68 healthy younger and older adults, ages 18–85. Methods Broadband near-infrared spectroscopy was used for the noninvasive quantification of bilateral cortical changes in oxidized cytochrome-c-oxidase and hemoglobin oxygenation before, during and after 1064-nm wavelength laser (IR-A laser, area: 13.6 cm2, power density: 250 mW/cm2) or sham stimulation of the right anterior prefrontal cortex (Brodmann Area 10). Results As compared to sham control, there was a significant laser-induced increase in oxidized cytochrome-c-oxidase during laser stimulation, followed by a significant post-stimulation increase in oxygenated hemoglobin and a decrease in deoxygenated hemoglobin. Furthermore, there was a greater laser-induced effect on cytochrome-c-oxidase with increasing age, while laser-induced effects on cerebral hemodynamics decreased with increasing age. No adverse laser effects were found. Conclusion The findings support the use of transcranial photobiomodulation for cerebral oxygenation and alleviation of age-related decline in mitochondrial respiration. They justify further research on its therapeutic potential in neurologic and psychiatric diseases. |
| Databáze: | OpenAIRE |
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