Usefulness of Serum Anti-p53 Antibody Measurement in Patients Undergoing Hepatectomy for Colorectal Liver Metastases
| Autor: | Satoshi Okubo, Miho Akabane, Yuta Kobayashi, Masaji Hashimoto, Junichi Shindoh, Kazutaka Kojima, Ryosuke Umino |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Colorectal cancer medicine.medical_treatment Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Biomarkers Tumor Hepatectomy Humans Clinical significance business.industry Hazard ratio Liver Neoplasms Perioperative medicine.disease Prognosis Cardiac surgery Carcinoembryonic Antigen Cardiothoracic surgery 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Surgery Neoplasm Recurrence Local business Colorectal Neoplasms Abdominal surgery |
| Zdroj: | World journal of surgery. 45(6) |
| ISSN: | 1432-2323 |
| Popis: | While anti-p53 antibody (p53-Ab) is a potential marker for early detection of colorectal cancer, its clinical utility in patients with advanced colorectal cancer remains unknown. The clinical significance of p53-Ab was investigated by analyzing the data of 206 patients who underwent curative resection for colorectal liver metastases. Of the 206 patients, 60 (29%) were seropositive and 146 were seronegative for p53-Ab before the surgery. The preoperative serum p53-Ab level showed no significant correlation with the serum CEA or serum CA19-9 levels. The perioperative changes in serum p53-Ab positivity were significantly correlated with the preoperative serum p53-Ab levels and multivariate analysis confirmed that a higher preoperative p53-Ab level was independently associated with a worse recurrence-free survival (hazard ratio [HR], 1.07; 95% CI, 1.01–1.13; P = 0.033 per + 100 U/mL), even after adjustments for other oncological factors, including the preoperative serum CEA level. Higher preoperative p53-Ab levels were associated with a higher risk of recurrence after curative resection of colorectal liver metastases. |
| Databáze: | OpenAIRE |
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