Plasma serotonin levels and suicidal behavior in adolescents
| Autor: | Ilanan Blum, Samuel Tyano, Hadas Ofek, Gil Zalsman, Luisa Wolovik, Alan Apter, Daniella Harell, Eliane Sommerfeld, Leo Sher, Abraham Weizman |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Serotonin Adolescent Personality Inventory Psychometrics media_common.quotation_subject Poison control Suicide Attempted Anger Impulsivity Suicide prevention Sex Factors medicine Electrochemistry Humans Pharmacology (medical) Psychiatry Child Biological Psychiatry Chromatography High Pressure Liquid media_common Pharmacology Psychiatric Status Rating Scales Depressive Disorder Suicide attempt Mental Disorders Beck Depression Inventory Aggression Psychiatry and Mental health Neurology Adolescent Behavior Anxiety Female Neurology (clinical) medicine.symptom Psychology Clinical psychology Psychopathology |
| Zdroj: | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 16(1) |
| ISSN: | 0924-977X |
| Popis: | To evaluate the relationship between plasma serotonin (p5-HT) levels and psychometric measures in suicidal adolescents vs. controls, 211 adolescents from three sites in Israel were divided into four groups: suicidal psychiatric inpatients (n=35); non-suicidal psychiatric inpatients (n=30); adolescents referred to the emergency room (ER) due to a suicide attempt (n=51); and a community-based control group from 4 high schools in the same catchment areas (n=95). All were interviewed and assessed for violence, aggression, depression, impulsivity, anger, anxiety, and p5-HT. p5-HT levels were significantly lower in the control group compared to all other groups. A significant negative correlation was found between p5-HT level and suicidal behavior severity among the suicidal inpatients. p5-HT did not discriminate between the psychiatric diagnostic categories and was significantly lower in ER violent compared to non-violent subjects. Gender, depression, and anger were associated with suicidal behavior in all four groups. Beck Depression Inventory (BDI) scores together with p5-HT levels discriminated between healthy controls and other groups. p5-HT level in combination with some of the psychometric scales may serve as a safe and inexpensive peripheral marker of psychopathology, and may help to differentiate between sub-populations of suicidal adolescents. The biological mechanism behind the serotonin dysregulation in suicidal adolescents requires further investigation. |
| Databáze: | OpenAIRE |
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