Longitudinal associations of physical activity with plasma metabolites among colorectal cancer survivors up to 2 years after treatment

Autor: Marc J. Gunter, Ilja C. W. Arts, Stephanie O. Breukink, Eline H. van Roekel, Michel Aquarius, Vivian Viallon, Linda van Delden, Augustin Scalbert, Michael F. Leitzmann, Sabina Rinaldi, Eric T.P. Keulen, Matty P. Weijenberg, Paolo Vineis, Audrey Gicquiau, Martijn J.L. Bours
Přispěvatelé: Epidemiologie, RS: GROW - R1 - Prevention, RS: CAPHRI - R3 - Functioning, Participating and Rehabilitation, Surgery, MUMC+: MA Heelkunde (9), RS: NUTRIM - R2 - Liver and digestive health, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Maastricht Centre for Systems Biology, RS: FHML MaCSBio, RS: FPN MaCSBio, RS: FSE MaCSBio, RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome
Rok vydání: 2021
Předmět:
Male
0301 basic medicine
Arginine
Epidemiology
Colorectal cancer
Metabolite
SERUM
chemistry.chemical_compound
0302 clinical medicine
Cancer Survivors
Tandem Mass Spectrometry
QUALITY-OF-LIFE
Interquartile range
REPRODUCIBILITY
Citrulline
Longitudinal Studies
Multidisciplinary
Middle Aged
Sphingomyelins
030220 oncology & carcinogenesis
TARGETED METABOLOMICS
Plasma concentration
Metabolome
Medicine
Female
HEALTH
Colorectal Neoplasms
After treatment
medicine.medical_specialty
Science
BIOMARKERS
QUESTIONNAIRE
Physical activity
Article
CLASSIFICATION
Gastrointestinal cancer
03 medical and health sciences
Cancer epidemiology
Carnitine
Internal medicine
medicine
Humans
Metabolomics
Histidine
Exercise
SIGNATURES
Aged
business.industry
MORTALITY
Lysophosphatidylcholines
medicine.disease
030104 developmental biology
Endocrinology
Risk factors
chemistry
Quality of Life
Self Report
business
Zdroj: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports, 11(1):13738. Nature Publishing Group
ISSN: 2045-2322
Popis: We investigated longitudinal associations of moderate-to-vigorous physical activity (MVPA) and light-intensity physical activity (LPA) with plasma concentrations of 138 metabolites after colorectal cancer (CRC) treatment. Self-reported physical activity data and blood samples were obtained at 6 weeks, and 6, 12 and 24 months post-treatment in stage I-III CRC survivors (n = 252). Metabolite concentrations were measured by tandem mass spectrometry (BIOCRATES AbsoluteIDQp180 kit). Linear mixed models were used to evaluate confounder-adjusted longitudinal associations. Inter-individual (between-participant differences) and intra-individual associations (within-participant changes over time) were assessed as percentage difference in metabolite concentration per 5 h/week of MVPA or LPA. At 6 weeks post-treatment, participants reported a median of 6.5 h/week of MVPA (interquartile range:2.3,13.5) and 7.5 h/week of LPA (2.0,15.8). Inter-individual associations were observed with more MVPA being related (FDR-adjusted q-value
Databáze: OpenAIRE
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