Longitudinal associations of physical activity with plasma metabolites among colorectal cancer survivors up to 2 years after treatment
Autor: | Marc J. Gunter, Ilja C. W. Arts, Stephanie O. Breukink, Eline H. van Roekel, Michel Aquarius, Vivian Viallon, Linda van Delden, Augustin Scalbert, Michael F. Leitzmann, Sabina Rinaldi, Eric T.P. Keulen, Matty P. Weijenberg, Paolo Vineis, Audrey Gicquiau, Martijn J.L. Bours |
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Přispěvatelé: | Epidemiologie, RS: GROW - R1 - Prevention, RS: CAPHRI - R3 - Functioning, Participating and Rehabilitation, Surgery, MUMC+: MA Heelkunde (9), RS: NUTRIM - R2 - Liver and digestive health, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Maastricht Centre for Systems Biology, RS: FHML MaCSBio, RS: FPN MaCSBio, RS: FSE MaCSBio, RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome |
Rok vydání: | 2021 |
Předmět: |
Male
0301 basic medicine Arginine Epidemiology Colorectal cancer Metabolite SERUM chemistry.chemical_compound 0302 clinical medicine Cancer Survivors Tandem Mass Spectrometry QUALITY-OF-LIFE Interquartile range REPRODUCIBILITY Citrulline Longitudinal Studies Multidisciplinary Middle Aged Sphingomyelins 030220 oncology & carcinogenesis TARGETED METABOLOMICS Plasma concentration Metabolome Medicine Female HEALTH Colorectal Neoplasms After treatment medicine.medical_specialty Science BIOMARKERS QUESTIONNAIRE Physical activity Article CLASSIFICATION Gastrointestinal cancer 03 medical and health sciences Cancer epidemiology Carnitine Internal medicine medicine Humans Metabolomics Histidine Exercise SIGNATURES Aged business.industry MORTALITY Lysophosphatidylcholines medicine.disease 030104 developmental biology Endocrinology Risk factors chemistry Quality of Life Self Report business |
Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021) Scientific Reports, 11(1):13738. Nature Publishing Group |
ISSN: | 2045-2322 |
Popis: | We investigated longitudinal associations of moderate-to-vigorous physical activity (MVPA) and light-intensity physical activity (LPA) with plasma concentrations of 138 metabolites after colorectal cancer (CRC) treatment. Self-reported physical activity data and blood samples were obtained at 6 weeks, and 6, 12 and 24 months post-treatment in stage I-III CRC survivors (n = 252). Metabolite concentrations were measured by tandem mass spectrometry (BIOCRATES AbsoluteIDQp180 kit). Linear mixed models were used to evaluate confounder-adjusted longitudinal associations. Inter-individual (between-participant differences) and intra-individual associations (within-participant changes over time) were assessed as percentage difference in metabolite concentration per 5 h/week of MVPA or LPA. At 6 weeks post-treatment, participants reported a median of 6.5 h/week of MVPA (interquartile range:2.3,13.5) and 7.5 h/week of LPA (2.0,15.8). Inter-individual associations were observed with more MVPA being related (FDR-adjusted q-value |
Databáze: | OpenAIRE |
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