Prevalence of and risk factors associated with latent tuberculosis in Singapore: A cross-sectional survey
| Autor: | Linda Wei Lin Tan, Mark I-Cheng Chen, Yee Tang Wang, Wei-Yen Lim, Kristin Hui Xian Tan, Peiling Yap, Cynthia B.E. Chee, Timothy Barkham |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Adult Male Tuberculosis Cross-sectional study 030106 microbiology Emigrants and Immigrants Asymptomatic QuantiFERON lcsh:Infectious and parasitic diseases 03 medical and health sciences Young Adult 0302 clinical medicine Latent Tuberculosis Risk Factors Environmental health Surveys and Questionnaires medicine Prevalence Humans Medical history lcsh:RC109-216 030212 general & internal medicine Aged Family Characteristics Singapore Latent tuberculosis Proportional hazards model business.industry Tuberculin Test Hazard ratio General Medicine Middle Aged medicine.disease bacterial infections and mycoses Health Surveys Infectious Diseases Cross-Sectional Studies Female medicine.symptom business Interferon-gamma Release Tests |
| Zdroj: | International Journal of Infectious Diseases, Vol 72, Iss, Pp 55-62 (2018) |
| ISSN: | 1201-9712 |
| Popis: | Objectives: This first cross-sectional survey on latent tuberculosis infection (LTBI) in Singapore was performed by utilizing the QuantiFERON Gold In-tube (QFT-GIT) assay to collect data on the prevalence of LTBI and to identify potential risk factors associated with LTBI. Methods: Nationwide household addresses were selected randomly for enumeration, and Singaporeans or Permanent Residents aged 18–79 years were identified. One eligible member per household was selected using the Kish grid. Each participant answered a questionnaire assessing their medical history (including tuberculosis (TB)), socio-economic factors, and lifestyle factors. They also provided a blood specimen for the QFT-GIT assay. Participants with a positive QFT-GIT result were defined as having LTBI if they were asymptomatic. To identify independent risk factors, adjusted hazard ratios were obtained using the multivariable modified Breslow–Cox proportional hazards model. Results: An overall QFT-GIT positivity rate of 12.7% was detected amongst 1682 Singapore residents. There was a wide variation in the positivity rate according to the participants’ country of birth. Higher LTBI prevalence was also significantly associated with increasing age, lower educational and socio-economic status, and alcohol use. Conclusions: Given the high prevalence of LTBI amongst foreign-born residents from regional countries, similar studies should be conducted amongst migrants in Singapore to improve national guidelines on screening and preventive treatment against LTBI. Keywords: Latent tuberculosis, Interferon-gamma release assay, Prevalence, Risk factors, Population |
| Databáze: | OpenAIRE |
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