Voxel-based analysis of PET amyloid ligand [11C]PIB uptake in Alzheimer disease
| Autor: | A. Brück, K. Någren, Marita Kailajärvi, Riitta Parkkola, I. A. Wilson, Matti Viitanen, Nina Kemppainen, Vesa Oikonen, Sargo Aalto, Juha O. Rinne, Mika Scheinin, Semi Helin |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Postmortem studies Pathology medicine.medical_specialty Amyloid Ligands computer.software_genre Statistical parametric mapping Central nervous system disease Alzheimer Disease Predictive Value of Tests Voxel Image Processing Computer-Assisted medicine Humans Benzothiazoles Carbon Radioisotopes Aged Aged 80 and over Cerebral Cortex Brain Mapping Amyloid beta-Peptides Aniline Compounds medicine.diagnostic_test business.industry Chemistry Brain Middle Aged medicine.disease Corpus Striatum Up-Regulation Thiazoles Positron emission tomography Positron-Emission Tomography Posterior cingulate Female Neurology (clinical) Alzheimer's disease Nuclear medicine business computer |
| Zdroj: | Neurology. 67:1575-1580 |
| ISSN: | 1526-632X 0028-3878 |
| Popis: | PET studies with N-methyl-[(11)C]2-(4':-methylaminophenyl)-6-hydroxybenzothiazole ([(11)C]PIB) have revealed an increased tracer uptake in several brain regions in Alzheimer disease (AD).To employ voxel-based analysis method to identify brain regions with significant increases in [(11)C]PIB uptake in AD vs healthy control subjects, indicative of increased amyloid accumulation in these regions.We studied 17 patients with AD and 11 control subjects with PET using [(11)C]PIB as tracer. Parametric images were computed by calculating a region-to-cerebellum ratio over 60 to 90 minutes in each voxel. Group differences in [(11)C]PIB uptake were analyzed with statistical parametric mapping (SPM) and automated region-of-interest (ROI) analysis.SPM showed increased uptake (p0.001) in the frontal, parietal, and lateral temporal cortices as well as in the posterior cingulate and the striatum. No significant differences in uptake were found in the primary sensory and motor cortices, primary visual cortex, thalamus, and medial temporal lobe. These results were supported by automated ROI analysis, with most prominent increases in AD subjects in the frontal cortex ([(11)C]PIB uptake 163% of the control mean) and posterior cingulate (146%) followed by the parietal (146%) and temporal (145%) cortices and striatum (133%), as well as small increases in the occipital cortex (117%) and thalamus (115%).Voxel-based analysis revealed widespread distribution of increased [(11)C]PIB uptake in Alzheimer disease (AD). These findings are in accordance with the distribution and phases of amyloid pathology in AD, previously documented in postmortem studies. |
| Databáze: | OpenAIRE |
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