The CADM2 Gene and Behavior: A Phenome-Wide Scan in UK-Biobank

Autor: Joëlle A. Pasman, Zeli Chen, Dirk J. A. Smit, Jacqueline M. Vink, Michel C. Van Den Oever, Tommy Pattij, Taco J. De Vries, Abdel Abdellaoui, Karin J. H. Verweij
Přispěvatelé: Epidemiology and Data Science, Anatomy and neurosciences, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Adult Psychiatry, ANS - Compulsivity, Impulsivity & Attention, APH - Mental Health, ANS - Complex Trait Genetics, Biological Psychology, Molecular and Cellular Neurobiology, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Behavior Genetics, 52(4-5), 306-314. Springer US
Behavior Genetics, 52, 4, pp. 306-314
Behavior genetics, 52(4-5), 306-314. Springer New York
Pasman, J A, Chen, Z, Smit, D J A, Vink, J M, Van Den Oever, M C, Pattij, T, De Vries, T J, Abdellaoui, A & Verweij, K J H 2022, ' The CADM2 Gene and Behavior : A Phenome-Wide Scan in UK-Biobank ', Behavior Genetics, vol. 52, no. 4-5, pp. 306-314 . https://doi.org/10.1007/s10519-022-10109-8
Pasman, J A, Chen, Z, Smit, D J A, Vink, J M, van den Oever, M C, Pattij, T, de Vries, T J, Abdellaoui, A & Verweij, K J H 2022, ' The CADM2 Gene and Behavior : A Phenome-Wide Scan in UK-Biobank ', Behavior Genetics, vol. 52, no. 4-5, pp. 306-314 . https://doi.org/10.1007/s10519-022-10109-8
Behavior Genetics, 52(4-5), 306-314. Springer
Behavior Genetics, 52, 306-314
Behavior Genetics. Springer US
ISSN: 0001-8244
DOI: 10.1007/s10519-022-10109-8
Popis: The cell adhesion molecule 2 (CADM2) gene has appeared among the top associations in a wide range of genome-wide association studies (GWASs). This study aims to: (1) examine how widespread the role of CADM2 is in behavioural traits, and (2) investigate trait-specific effects on CADM2 expression levels across tissues. We conducted a phenome-wide association study in UK Biobank (N = 12,211–453,349) on 242 psycho-behavioral traits, both at the SNP and the gene-level. For comparison, we repeated the analyses for other large (and high LD) genes. We found significant associations between CADM2 and 50 traits (including cognitive, risk taking, and dietary traits), many more than for the comparison genes. We show that many trait associations are reduced when taking geographical stratification into account. S-Predixcan revealed that CADM2 expression in brain tissues was significantly associated with many traits; highly significant effects were also observed for lung, mammary, and adipose tissues. In conclusion, this study shows that the role of CADM2 extends to a wide range of psycho-behavioral traits, suggesting these traits may share a common biological denominator.
Databáze: OpenAIRE
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