Houttuynia cordata polysaccharide alleviated intestinal injury and modulated intestinal microbiota in H1N1 virus infected mice

Autor: Xiao-Xiao Lu, Lijun Ling, Daofeng Chen, Hong-Bo Weng, Yun-Yi Zhang, Mei-Yu Chen, Hong Li, Wei Sun
Rok vydání: 2019
Předmět:
Male
Inflammation
Lung injury
Gut flora
Polysaccharide
01 natural sciences
Article
Microbiology
03 medical and health sciences
H1N1 influenza virus
Influenza A Virus
H1N1 Subtype
0302 clinical medicine
Orthomyxoviridae Infections
Polysaccharides
Oral administration
Drug Discovery
medicine
Animals
Houttuynia
Intestinal Mucosa
Receptor
Lung
chemistry.chemical_classification
Mice
Inbred BALB C
biology
Plant Extracts
010405 organic chemistry
Microbiota
Toll-Like Receptors
General Medicine
Hypoxia (medical)
Hypoxia-Inducible Factor 1
alpha Subunit
biology.organism_classification
Gastrointestinal Microbiome
0104 chemical sciences
Houttuynia cordata
Complementary and alternative medicine
chemistry
Intestinal Barrier
030220 oncology & carcinogenesis
Zonula Occludens-1 Protein
Cytokines
medicine.symptom
Drugs
Chinese Herbal
Zdroj: Chinese Journal of Natural Medicines
ISSN: 1875-5364
DOI: 10.1016/s1875-5364(19)30021-4
Popis: Houttuynia cordata polysaccharide (HCP) is extracted from Houttuynia cordata, a key traditional Chinese medicine. The study was to investigate the effects of HCP on intestinal barrier and microbiota in H1N1 virus infected mice. Mice were infected with H1N1 virus and orally administrated HCP at a dosage of 40 mg(kg−1(d−1. H1N1 infection caused pulmonary and intestinal injury and gut microbiota imbalance. HCP significantly suppressed the expression of hypoxia inducible factor-1α and decreased mucosubstances in goblet cells, but restored the level of zonula occludens-1 in intestine. HCP also reversed the composition change of intestinal microbiota caused by H1N1 infection, with significantly reduced relative abundances of Vibrio and Bacillus, the pathogenic bacterial genera. Furthermore, HCP rebalanced the gut microbiota and restored the intestinal homeostasis to some degree. The inhibition of inflammation was associated with the reduced level of Toll-like receptors and interleukin-1β in intestine, as well as the increased production of interleukin-10. Oral administration of HCP alleviated lung injury and intestinal dysfunction caused by H1N1 infection. HCP may gain systemic treatment by local acting on intestine and microbiota. This study proved the high-value application of HCP.
Databáze: OpenAIRE
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