CUSHING'S SYNDROME WITH MULTINODULAR ADRENAL GLANDS*
| Autor: | Drake W. Will, H. David Mosier, Pierce J. Flynn, Roderick D. Turner |
|---|---|
| Rok vydání: | 1960 |
| Předmět: |
Pregnanetriol
medicine.medical_specialty Endocrinology Diabetes and Metabolism Urinary system Clinical Biochemistry Stimulation Biochemistry Lesion Excretion chemistry.chemical_compound Cushing syndrome Endocrinology Cortex (anatomy) Internal medicine Adrenal Glands Biopsy medicine Humans Cushing Syndrome medicine.diagnostic_test business.industry Biochemistry (medical) medicine.disease medicine.anatomical_structure chemistry medicine.symptom business |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 20:632-640 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-20-4-632 |
| Popis: | A case of Cushing's syndrome in a 15-year-old girl with symptoms of one year's duration, is described. The levels of plasma and urinary 17-hydroxycorticostcroids and urinary 17-ketogenic steroids were elevated but the levels of urinary 17-ketosteroids and pregnanetriol were normal. Stimulation with ACTH produced a low, sluggish response in the concentration of plasma 17-hydroxycorticosteroids and only minimal changes in urinary steroids. Administration of 9α-fluorohydrocortisone produced no change in urinary steroid excretion. Following bilateral adrenalectomy the manifestations of Cushing's syndrome disappeared. The adrenals showed diffuse multinodularity of the inner cortex. The relation of this lesion to other adrenal lesions producing Cushing's syndrome is discussed. MELLINGER and Smith in 1956 reported an unusual case of Cushing's syndrome of about thirty years' duration in a patient who had multiple small nodules throughout the cortex of one adrenal. Biopsy of the same gland earlier in the ... |
| Databáze: | OpenAIRE |
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