Multiple Reactivations of Viral Infections Followed by Cerebral Toxoplasmosis After Allogeneic Hematopoietic Stem Cell Transplantation in an Adolescent With Ph(+) Acute Lymphoblastic Leukemia: A Case Report
| Autor: | Katarzyna Jończyk-Potoczna, Olga Zając-Spychała, Anna Pieczonka, Jacek Wachowiak, J. Janura-Szymańska |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Herpesvirus 4 Human Adolescent Lymphoblastic Leukemia medicine.medical_treatment Cytomegalovirus Herpesvirus 1 Human Hematopoietic stem cell transplantation Antiviral Agents Unrelated Donor medicine Humans Philadelphia Chromosome Immunosuppressive treatment Transplantation business.industry Hematopoietic Stem Cell Transplantation Precursor Cell Lymphoblastic Leukemia-Lymphoma Magnetic Resonance Imaging Ph+ acute lymphoblastic leukemia Multiple infections Highly sensitive Cerebral toxoplasmosis Virus Diseases Toxoplasmosis Cerebral Immunology Surgery Unrelated Donors business |
| Zdroj: | Transplantation Proceedings. 53:1355-1359 |
| ISSN: | 0041-1345 |
| DOI: | 10.1016/j.transproceed.2021.02.007 |
| Popis: | After allogeneic hematopoietic stem cell transplantation (allo-HSCT), especially from an unrelated donor, infectious complications are frequent and severe, sometimes with fatal outcomes. Despite using highly sensitive molecular techniques for close monitoring in the early post-transplant period for early diagnosis, not every viral infection or reactivation can be detected adequately early, even with highly sensitive methods. Particularly after toxic and deeply immunosuppressive treatment, multiple infections or reactivations, uncommon infections, or infections in unusual locations can occur. Here, we present a case of multiple viral infections or reactivations and cerebral toxoplasmosis in a 17-year-old youth with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) treated with allo-HSCT who suffered multiple viral infections followed by cerebral toxoplasmosis. |
| Databáze: | OpenAIRE |
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