Impact of Dosing Intervals on Activity of Gentamicin and Ticarcillin Against Pseudomonas aeruginosa in Granulocytopenic Mice
| Autor: | Charlotte Feller, H. P. Brugger, A. P. Vastola, William A. Craig, Andreas U. Gerber, J. Brandel |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.drug_class
Antibiotics Penicillins Biology Pharmacology medicine.disease_cause Drug Administration Schedule Mice Antimicrobial chemotherapy medicine polycyclic compounds Immunology and Allergy Animals Ticarcillin Pseudomonas Infections heterocyclic compounds Dosing Mice Inbred ICR Dose-Response Relationship Drug Pseudomonas aeruginosa Aminoglycoside biochemical phenomena metabolism and nutrition Antimicrobial bacterial infections and mycoses Kinetics Infectious Diseases bacteria Gentamicin Drug Therapy Combination Female Gentamicins medicine.drug Agranulocytosis |
| Zdroj: | Gerber, A. U.; Craig, W. A.; Brugger, H.-P.; Feller, C.; Vastola, A. P.; Brandel, J. (1983). Impact of Dosing Intervals on Activity of Gentamicin and Ticarcillin Against Pseudomonas aeruginosa in Granulocytopenic Mice. Journal of infectious diseases, 147(5), pp. 910-917. The University of Chicago Press 10.1093/infdis/147.5.910 |
| DOI: | 10.1093/infdis/147.5.910 |
| Popis: | The influence of dosing intervals on the activity of gentamicin and ticarcillin against Pseudomonas aeruginosa was studied in vivo. Granulocytopenic mice infected with P. aeruginosa in the thigh muscle were treated with 1-hr or 3-hr injections of gentamicin, ticarcillin, or gentamicin-ticarcillin. Plasma pharmacokinetics of the drugs were correlated with antibacterial activity. Gentamicin injected every 1 hr tended to be less active than gentamicin injected at longer intervals. In contrast, ticarcillin given every 1 hr was significantly more efficacious than equivalent total doses injected every 3 hr. The dosing schedule of gentamicin-ticarcillin was again important for ticarcillin but did not appreciably affect the antibacterial activity of gentamicin. Thus, antimicrobial chemotherapy of P. aeruginosa infections in the granulocytopenic host might be improved by administering ticarcillin rather than gentamicin as a constant infusion. The optimal antibiotic treatment of gram-negative bacterial infections in granulocytopenic patients remains an unsolved clinical problem, particularly for infections due to Pseudomonas aeruginosa, although progress has been made by combining antipseudomonal drugs and by using doses approaching toxic levels. Additional progress could possibly be made by finding optimal dosing schedules for these drugs. This aspect of antimicrobial chemotherapy has hardly been investigated. In some recent clinical trials aminoglycoside antibiotics were administered as constant |
| Databáze: | OpenAIRE |
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