Diaphragmatic muscle thickness in older people with and without sarcopenia
Autor: | Hacer Dogan Varan, Mehmet Can Pence, Nur Betul Karatoprak, Berna Goker, Olgun Deniz, Muhammet Cemal Kizilarslanoglu, Suna Özhan Oktar, Suheyla Coteli |
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Rok vydání: | 2020 |
Předmět: |
Aging
medicine.medical_specialty Sarcopenia Diaphragmatic breathing 03 medical and health sciences Mice 0302 clinical medicine Internal medicine Diaphragm muscle medicine Animals Humans 030212 general & internal medicine Respiratory system Peak flow meter Geriatric Assessment measurement_unit Aged Aged 80 and over business.industry Muscles Geriatric assessment medicine.disease Diaphragm (structural system) Respiratory Function Tests Cross-Sectional Studies measurement_unit.measuring_instrument Cardiology Geriatrics and Gerontology business Older people 030217 neurology & neurosurgery |
Zdroj: | Aging clinical and experimental research. 33(3) |
ISSN: | 1720-8319 |
Popis: | Background Studies in mice have suggested that sarcopenic animals may have atrophic diaphragmatic muscles; however, to date, no clinical studies are available. Aims To investigate whether the diaphragmatic thickness is affected in older patients with sarcopenia and if this is associated with impaired respiratory functions. Methods Thirty sarcopenic and 30 non-sarcopenic elderly patients aged over 65 were included. All patients underwent comprehensive geriatric assessment. The diagnosis of sarcopenia was made according to the criteria of the European Working Group on Sarcopenia in Older People. Ultrasonographic evaluations of the patients were carried out by an experienced radiologist. Diaphragmatic thickness was measured in three positions: end of deep inspiration, quiet breathing, end of forced expiration. Peak expiratory flow (PEF) rate was evaluated by a peak flow meter. Results The mean age of the patients was 77 +/- 6 years, and 58% were females. Diaphragmatic thickness in three different positions (deep inspiration [2.3 mm (min-max: 1.3-4.1) vs. 2.5 mm (min-max: 1.9-4.9)], quiet breathing [1.8 mm (min-max: 1.0-2.8) vs. 2.00 mm (min-max: 1.3-3.9)] and end of forced expiration [1.1 mm (min-max: 0.7-2.5) vs. 1.5 mm (min-max: 0.5-3.4)]) were found to be thinner in sarcopenic patients compared to non-sarcopenics (p = 0.02, p = 0.02, p < 0.01, respectively). Also, PEF rate results were lower in patients with sarcopenia (245 L/min [min-max: 150-500] vs. 310 L/min [min-max: 220-610], p < 0.01). Diaphragmatic muscle thicknesses in all three positions were independently associated with sarcopenia status of the participants. Conclusions Our results suggest that sarcopenia in older people may be associated with reduced diaphragmatic muscle thickness and respiratory functions. Findings are needed to be confirmed in further multicenter studies with big sample sizes. |
Databáze: | OpenAIRE |
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