Association of angiotensin-converting enzyme and angiotensin II type I receptor gene polymorphisms with extreme obesity in Polish individuals
Autor: | Przemysław Adamczyk, Jacek Chojnowski, Irena Ponikowska, Tomasz Ferenc, Marta Pacholczyk, Jan Kowalski |
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Rok vydání: | 2013 |
Předmět: |
Adult
Male medicine.medical_specialty Genotype Adipose tissue Peptidyl-Dipeptidase A Receptor Angiotensin Type 1 Internal medicine Genetics medicine Humans Genetic Predisposition to Disease Molecular Biology Gene Genetic Association Studies Aged Enzyme Gene Extreme obesity Polymorphism Genetic biology Type 2 Diabetes Mellitus Angiotensin-converting enzyme Epistasis Genetic Cell Biology General Medicine Middle Aged Angiotensin II Obesity Morbid Endocrinology Diabetes Mellitus Type 2 Case-Control Studies biology.protein Female Poland |
Zdroj: | DNA and cell biology. 32(8) |
ISSN: | 1557-7430 |
Popis: | There is strong evidence for the presence of a functional renin-angiotensin system in human adipose tissue. The aim of our study was to investigate the association of polymorphic variants of angiotensin-converting enzyme gene (ACE I/D) and angiotensin II type I receptor gene (AGTR1 A1166C) with extreme obesity and obesity-associated type 2 diabetes mellitus (T2DM) and to examine their combined effect on extremely obese patients. Overall, no significant associations were detected between ACE and AGTR1 gene polymorphisms and extreme obesity. However, extremely obese patients with T2DM showed an increased frequency of ACE II genotype compared with controls (p0.05) and with non-diabetic extremely obese patients (p0.01). The results suggest that II genotype of ACE was a significant contributor to extreme obesity in AA homozygotes of AGTR1 gene, regardless of the presence of T2DM. Moreover, the analysis of genetic polymorphisms demonstrated that ACE II and AGTR1 AC genotypes were most frequently observed in patients with extreme obesity and T2DM. On the basis of our results, we suggest that ACE II homozygosity may be a significant predictor of extreme obesity and T2DM and that the interaction between ACE and AGTR1 genes may be considered a predisposing factor for extreme obesity and extreme obesity-associated T2DM development. |
Databáze: | OpenAIRE |
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