The Imidazopyridine Derivative JK184 Reveals Dual Roles for Microtubules in Hedgehog Signaling
| Autor: | Surajit Sinha, Joel M. Hyman, Ari J. Firestone, James K. Chen, Kyuho Han, Cory A. Ocasio, Paul G. Rack, Tommaso Cupido |
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| Rok vydání: | 2009 |
| Předmět: |
animal structures
Pyridines macromolecular substances Heterocyclic Compounds 2-Ring Microtubules Catalysis Cell Line Mice Microtubule Animals Hedgehog Proteins Cytoskeleton Hedgehog Regulation of gene expression Chemistry Gene Expression Regulation Developmental General Chemistry Embryonic stem cell Hedgehog signaling pathway Cell biology Thiazoles Biochemistry Cell culture embryonic structures NIH 3T3 Cells Signal transduction Signal Transduction |
| Zdroj: | Angewandte Chemie International Edition. 48:2321-2324 |
| ISSN: | 1433-7851 |
| DOI: | 10.1002/anie.200805666 |
| Popis: | Eradicating hedgehogs: The title molecule has been previously identified as a potent inhibitor of the Hedgehog signaling pathway, which gives embryonic cells information needed to develop properly. This molecule is shown to modulate Hedgehog target gene expression by depolymerizing microtubules, thus revealing dual roles of the cytoskeleton in pathway regulation (see figure). |
| Databáze: | OpenAIRE |
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