Flavonoid biosynthetic pathways in plants: Versatile targets for metabolic engineering
Autor: | Ipek Süntar, Maria Daglia, Luca Rastrelli, Solomon Habtemariam, Samira Shirooie, Bahman Yousefi, Philippe Jeandet, Francesca Giampieri, Seyed Mohammad Nabavi, Luigi Milella, Suowen Xu, Daniela Russo, Dunja Šamec, Jianbo Xiao, Eduardo Sobarzo-Sánchez, Seyed Fazel Nabavi, Maurizio Battino, Michał Tomczyk |
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Přispěvatelé: | Résistance Induite et Bioprotection des Plantes - EA 4707 (RIBP), Université de Reims Champagne-Ardenne (URCA)-SFR Condorcet, Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS), Nabavi, S. M., Samec, D., Tomczyk, M., Milella, L., Russo, D., Habtemariam, S., Suntar, I., Rastrelli, L., Daglia, M., Xiao, J., Giampieri, F., Battino, M., Sobarzo-Sanchez, E., Nabavi, S. F., Yousefi, B., Jeandet, P., Xu, S., Shirooie, S. |
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0106 biological sciences
[SDV]Life Sciences [q-bio] Flavonoid Bioengineering Computational biology Biology 01 natural sciences Applied Microbiology and Biotechnology Metabolic engineering 03 medical and health sciences chemistry.chemical_compound Biosynthesis 010608 biotechnology Shikimic acid ComputingMilieux_MISCELLANEOUS 030304 developmental biology chemistry.chemical_classification Flavonoids 0303 health sciences Acetate fungi food and beverages Plant Biosynthetic Pathway Plants 3. Good health Biosynthetic Pathways Metabolic pathway chemistry Metabolic Engineering Biotechnology |
Zdroj: | Biotechnology Advances Biotechnology Advances, Elsevier, 2020, 38, pp.107316. ⟨10.1016/j.biotechadv.2018.11.005⟩ |
ISSN: | 0734-9750 |
Popis: | Plants, fungi, and microorganisms are equipped with biosynthesis machinery for producing thousands of secondary metabolites. These compounds have important functions in nature as a defence against predators or competitors as well as other ecological significances. The full utilization of these compounds for food, medicine, and other purposes requires a thorough understanding of their structures and the distinct biochemical pathways of their production in cellular systems. In this review, flavonoids as classical examples of secondary metabolites are employed to highlight recent advances in understanding how valuable compounds can be regulated at various levels. With extensive diversity in their chemistry and pharmacology, understanding the metabolic engineering of flavonoids now allows us to fine-tune the eliciting of their production, accumulation, and extraction from living systems. More specifically, recent advances in the shikimic acid and acetate biosynthetic pathways of flavonoids production from metabolic engineering point of view, from genes expression to multiple principles of regulation, are addressed. Specific examples of plants and microorganisms as the sources of flavonoids-based compounds with particular emphasis on therapeutic applications are also discussed. |
Databáze: | OpenAIRE |
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