Decreased serum zinc concentration in dogs with lymphocytic-plasmacytic enteritis, and its associations with disease severity and prognosis
| Autor: | Tomoyo Nabetani, Kosei Sakai, Shunsuke Shimamura, Hiroyuki Tani, Shingo Hatoya, Terumasa Shimada, Masaru Furuya |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Poor prognosis Clinical Pathology 040301 veterinary sciences chemistry.chemical_element Zinc Gastroenterology Inflammatory bowel disease Enteritis 0403 veterinary science 03 medical and health sciences Dogs Disease severity Internal medicine medicine Animals Dog Diseases 030304 developmental biology 0303 health sciences General Veterinary Serum zinc business.industry zinc 04 agricultural and veterinary sciences Lymphocytic-plasmacytic enteritis Prognosis Note medicine.disease Survival Analysis chemistry dog lymphocytic-plasmacytic enteritis Biomarker (medicine) Female disease severity business Biomarkers |
| Zdroj: | The Journal of Veterinary Medical Science |
| ISSN: | 1347-7439 0916-7250 |
| Popis: | Human patients with inflammatory bowel disease may have poor prognosis with hypozincemia. However, there are limited data on zinc concentrations in the blood of dogs with lymphocytic-plasmacytic enteritis (LPE). The purpose of this study was to investigate the serum zinc concentration in dogs with LPE and its influence on disease severity and prognosis. Thirty-five dogs with LPE were recruited. Serum zinc concentration was measured using atomic absorption spectrometry. Hypozincemia was observed in 18/35 (51%) dogs with LPE. Serum zinc concentration was inversely correlated with histological and clinical severities. Overall survivals were significantly shorter in dogs with hypozincemia than in those without it. These findings suggest that serum zinc concentration is a useful biomarker for LPE severity and prognosis in dogs. |
| Databáze: | OpenAIRE |
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