Type I interferons in ray-finned fish (Actinopterygii)
| Autor: | Beata Tokarz-Deptuła, Wiesław Deptuła, M. Stosik |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Fish Proteins Phagocytosis Aquatic Science Perciformes Evolution Molecular 03 medical and health sciences Immune system Environmental Chemistry Animals Gene biology Fishes 04 agricultural and veterinary sciences General Medicine biology.organism_classification Molecular biology Hedgehog signaling pathway Nitric oxide synthase 030104 developmental biology Interferon Type I 040102 fisheries STAT protein biology.protein 0401 agriculture forestry and fisheries Janus kinase |
| Zdroj: | Fishshellfish immunology. 110 |
| ISSN: | 1095-9947 |
| Popis: | Interferons (IFNs) are proteins of vital importance in the body's immune response. They are formed in different types of cells and have been found in fish, amphibians, reptiles and mammals. Two types of IFN have been found in ray-finned fish (Superclass: Osteichthyes, Class: Actinopterygii) so far, i.e. IFN type I (IFN I) and IFN type II (IFN II), while the presence of IFN type III (IFN III), which is found in phylogenetically older cartilaginous fishes, was not confirmed in this taxonomic group of vertebrates. Currently, type I IFN in Actinopterygii is divided into three groups, I, II and III, within which there are subgroups. These cytokines in these animals show primarily antiviral activity through the use of a signalling pathway JAK-STAT (Janus kinases — Signal transducer and activator of transcription) and the ability to induce ISG (IFN-stimulated genes) expression, which contain ISRE complexes (IFN-stimulated response elements). On the other hand, in Perciformes and Cyprinidae, it was found that type I/I interferons also participate in the antimicrobial response, inter alia, by inducing the expression of the inducible nitric oxide synthase (iNOS) and influencing the production of reactive oxygen species (ROS) in cells carrying out the phagocytosis process. |
| Databáze: | OpenAIRE |
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