Evaluating effects of black carrot extract on testicular carboxylesterase activity and oxidative stress parameters in rats exposed to Bisphenol A
| Autor: | Miraç Uçkun, Zafer Sahin, Ertan Yoloğlu, Yunus Şahin, Ahmet Özkaya, Ozgur Bulmus |
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| Rok vydání: | 2021 |
| Předmět: |
endocrine system
Bisphenol A Black carrot Testis Carboxylesterase Oxidative stress Rat Bisphenol A Carboxylesterase activity urogenital system Chemistry Multidisciplinary Carrot extract food and beverages General Medicine medicine.disease_cause chemistry.chemical_compound Carboxylesterase chemistry medicine Food science Kimya Ortak Disiplinler hormones hormone substitutes and hormone antagonists Oxidative stress |
| Zdroj: | Volume: 11, Issue: 1 73-86 Adıyaman University Journal of Science |
| ISSN: | 2147-1630 2146-586X |
| Popis: | We aimed to evaluate the effects of black carrot extract on testicular carboxylesterase (Ces) activity, malondialdehyde (MDA), glutathione S-transferases (GST) and reduced glutathione (GSH) in male rats exposed to bisphenol A (BPA). Adult Wistar albino male rats were divided into 4 groups as follows (n = 7/group): control, BPA, black carrot and BPA+Black carrot. Testicular Ces, MDA, GST and reduced GSH were analyzed by using a spectrophotometer system. Testicular Ces activity was significantly lower only in the BPA group than the control group (p < 0.001). Testicular MDA concentrations were higher only in the BPA group compared with the control group (p < 0.001). Reduced GSH level was higher in the black carrot and BPA+Black carrot groups than the control group (p < 0.05). GST activity was lower in the BPA group in comparison to the control group (p < 0.05). In the black carrot and BPA+Black carrot groups, the GST activities were higher than the control group (p < 0.001). Our results showed BPA suppresses testicular detoxification activity and increases lipid peroxidation in rats. We observed that black carrot extract has a beneficial effect on the toxic and oxidative stress-related parameters caused by BPA exposure. |
| Databáze: | OpenAIRE |
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