Characterization of an insulin-like growth factor (IGF) receptor and the insulin-like effects of IGF-1 in the bony fish, Lates calcarifer
| Autor: | Alex J Anderson, Geoff Carey, Peter B. Mather, Katarina Drakenberg, Vicki R. Sara |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Physiology Barramundi medicine.medical_treatment Clinical Biochemistry Stimulation Biochemistry Binding Competitive law.invention Cellular and Molecular Neuroscience Insulin-like growth factor chemistry.chemical_compound Endocrinology law Internal medicine medicine Animals Humans Insulin Insulin-Like Growth Factor I Receptor Muscle Skeletal Pancreatic hormone Phylogeny biology Glycogen Fishes Receptors Somatomedin biology.organism_classification Recombinant Proteins chemistry Liver Recombinant DNA |
| Zdroj: | Regulatory peptides. 69(1) |
| ISSN: | 0167-0115 |
| Popis: | The present work is part of a broad phylogenetic study of the insulin superfamily of peptides in lower vertebrates. In the bony fish barramundi (Lates calcarifer), the presence of IGF receptors were investigated in the liver by means of competitive binding studies. The results suggested the presence of a type 1-like but no type 2-like IGF receptor. We also demonstrated insulin-like effects of intraperitoneally injected recombinant human (rh)-IGF-1 in barramundi with rh-IGF-1 and rh-insulin showing similar effects with respect to induction of hypoglycemia and stimulation of incorporation of [14C]-glucose into muscle glycogen. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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