Elevated serum lipoprotein(a) level is an independent marker of severity of thoracic aortic atherosclerosis
| Autor: | Marcel Peltier, Jean Philippe M. Lesbre, Jean Laurent Colas, Micheèle C.Iannetta Peltier, Christophe Tribouilloy, Maurice E. Sarano |
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| Rok vydání: | 2002 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male medicine.medical_specialty Arteriosclerosis Aortic Diseases Aorta Thoracic Coronary Artery Disease Critical Care and Intensive Care Medicine Coronary Angiography Coronary artery disease chemistry.chemical_compound Risk Factors Internal medicine medicine.artery medicine Thoracic aorta Humans Prospective Studies Risk factor Aged Aortic atherosclerosis Aged 80 and over Univariate analysis biology Vascular disease business.industry Lipoprotein(a) Middle Aged medicine.disease chemistry Low-density lipoprotein Multivariate Analysis biology.protein Cardiology Regression Analysis Female Cardiology and Cardiovascular Medicine business Biomarkers Echocardiography Transesophageal |
| Zdroj: | Chest. 121(5) |
| ISSN: | 0012-3692 |
| Popis: | Study objective: Lipoprotein(a) (Lp[a]) level is a risk factor for ischemic heart disease, cerebrovascular disease, and peripheral vascular disease. However, few data are available concerning the relationship between Lp(a) level and severity of thoracic aortic atherosclerosis. We hypothesized in this transesophageal echocardiography (TEE) study that Lp(a) level is a marker of severity of thoracic aortic atherosclerosis. Design: Cross-sectional study. Setting: University hospital. Patients: Risk factors, coronary angiographic features, and TEE findings were analyzed prospectively in 119 patients with valvular disease. Measurements and results: The following risk factors were recorded: age, gender, hypertension, smoking, lipid parameters, diabetes, body mass index, and family history of coronary artery disease. Serum levels of Lp(a) were measured for each patient. By univariate analysis, age, diabetes, hypertension, smoking, Lp(a), total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol levels were significant predictors of thoracic aortic atherosclerosis. There was a positive and significant correlation between the Lp(a) levels and the score of severity of thoracic aortic atherosclerosis (p 0.0001). Multivariate regression analysis revealed that Lp(a) was an independent predictor of severity of thoracic aortic atherosclerosis (p 0.0001). Conclusion: This prospective study indicates that serum Lp(a) level is an independent marker of severity of thoracic aortic atherosclerosis detected by multiplane TEE. These findings emphasize the role of Lp(a) as a marker of atherosclerotic lesions in the major arterial locations. (CHEST 2002; 121:1589 –1594) |
| Databáze: | OpenAIRE |
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