Synthesis of 1H-pyrazolo[3,4-d]pyrimidines via solid-phase Aza-Wittig/electrocyclic ring closure reaction
| Autor: | Bruce C. Hamper, Li Xing, Liao Subo |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Pyrazolo[3
4-d]pyrimidine Pyrimidine Solid-phase synthesis Chemistry Stereochemistry Organic Chemistry Heterocyclic Closure (topology) Combinatorial chemistry Aza-Wittig reaction Ring (chemistry) Biochemistry Electrocyclization ring closure chemistry.chemical_compound Phase (matter) Wittig reaction Drug Discovery Amine gas treating |
| Zdroj: | Tetrahedron Letters. (50):6855-6857 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/j.tetlet.2013.10.021 |
| Popis: | An elegant solid-phase synthetic route of pyrazolo[3,4-d]pyrimidine derivatives via Aza-Wittig/electrocyclic ring closure reaction was developed and validated. By manipulating the R group from the primary amine building block, one can easily prepare the library of pyrazolo[3,4-d]pyrimidine derivatives. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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